Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence

Accumulation of senescent cells with age is an important driver of aging and age-related diseases. However, the mechanisms and signaling pathways that regulate senescence remain elusive. In this report, we performed post-genome-wide association studies (GWAS) functional studies on the CDKN2A/B locus...

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Detalles Bibliográficos
Autores principales: Jiang, Danli, Sun, Wei, Wu, Ting, Zou, Meijuan, Vasamsetti, Sathish Babu, Zhang, Xiaoyu, Zhao, Yihan, Phillippi, Julie A., Sawalha, Amr H., Tavakoli, Sina, Dutta, Partha, Florentin, Jonathan, Chan, Stephen Y., Tollison, Tammy S., Di Wu, Cui, Jing, Huntress, Ian, Peng, Xinxia, Finkel, Toren, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154215/
https://www.ncbi.nlm.nih.gov/pubmed/37117763
http://dx.doi.org/10.1038/s43587-022-00177-0

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