An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating sST2 le...

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Detalles Bibliográficos
Autores principales: Jiang, Yuanbing, Zhou, Xiaopu, Wong, Hiu Yi, Ouyang, Li, Ip, Fanny C. F., Chau, Vicky M. N., Lau, Shun-Fat, Wu, Wei, Wong, Daniel Y. K., Seo, Heukjin, Fu, Wing-Yu, Lai, Nicole C. H., Chen, Yuewen, Chen, Yu, Tong, Estella P. S., Mok, Vincent C. T., Kwok, Timothy C. Y., Mok, Kin Y., Shoai, Maryam, Lehallier, Benoit, Losada, Patricia Morán, O’Brien, Eleanor, Porter, Tenielle, Laws, Simon M., Hardy, John, Wyss-Coray, Tony, Masters, Colin L., Fu, Amy K. Y., Ip, Nancy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154240/
https://www.ncbi.nlm.nih.gov/pubmed/37117777
http://dx.doi.org/10.1038/s43587-022-00241-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154240/
https://www.ncbi.nlm.nih.gov/pubmed/37117777
http://dx.doi.org/10.1038/s43587-022-00241-9

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