Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8(+) T cells

To date, no immunotherapy approaches have managed to fully overcome T-cell exhaustion, which remains a mandatory fate for chronically activated effector cells and a major therapeutic challenge. Understanding how to reprogram CD8(+) tumor-infiltrating lymphocytes away from exhausted effector states r...

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Detalles Bibliográficos
Autores principales: Corria-Osorio, Jesus, Carmona, Santiago J., Stefanidis, Evangelos, Andreatta, Massimo, Ortiz-Miranda, Yaquelin, Muller, Tania, Rota, Ioanna A., Crespo, Isaac, Seijo, Bili, Castro, Wilson, Jimenez-Luna, Cristina, Scarpellino, Leonardo, Ronet, Catherine, Spill, Aodrenn, Lanitis, Evripidis, Romero, Pedro, Luther, Sanjiv A., Irving, Melita, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154250/
https://www.ncbi.nlm.nih.gov/pubmed/37081150
http://dx.doi.org/10.1038/s41590-023-01477-2

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