Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma

Group 3 medulloblastoma (G3 MB) carries the worst prognosis of all MB subgroups. MYC oncoprotein is elevated in G3 MB tumors; however, the mechanisms that support MYC abundance remain unclear. Using metabolic and mechanistic profiling, we pinpoint a role for mitochondrial metabolism in regulating MY...

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Detalles Bibliográficos
Autores principales: Martell, Emma, Kuzmychova, Helgi, Kaul, Esha, Senthil, Harshal, Chowdhury, Subir Roy, Morrison, Ludivine Coudière, Fresnoza, Agnes, Zagozewski, Jamie, Venugopal, Chitra, Anderson, Chris M., Singh, Sheila K., Banerji, Versha, Werbowetski-Ogilvie, Tamra E., Sharif, Tanveer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154337/
https://www.ncbi.nlm.nih.gov/pubmed/37130865
http://dx.doi.org/10.1038/s41467-023-38049-9

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