A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner

Cells are inevitably challenged by low-level/endogenous stresses that do not arrest DNA replication. Here, in human primary cells, we discovered and characterized a noncanonical cellular response that is specific to nonblocking replication stress. Although this response generates reactive oxygen spe...

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Detalles Bibliográficos
Autores principales: Ragu, Sandrine, Droin, Nathalie, Matos-Rodrigues, Gabriel, Barascu, Aurélia, Caillat, Sylvain, Zarkovic, Gabriella, Siberchicot, Capucine, Dardillac, Elodie, Gelot, Camille, Guirouilh-Barbat, Josée, Radicella, J. Pablo, Ishchenko, Alexander A., Ravanat, Jean-Luc, Solary, Eric, Lopez, Bernard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154342/
https://www.ncbi.nlm.nih.gov/pubmed/36869180
http://dx.doi.org/10.1038/s41418-023-01141-0

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