Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy

The pathological hallmark of multiple system atrophy (MSA) is aberrant accumulation of phosphorylated α‐synuclein in oligodendrocytes, forming glial cytoplasmic inclusions (GCIs). Extensive demyelination occurs particularly in the olivopontocerebellar and striatonigral pathways, but its precise mech...

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Detalles Bibliográficos
Autores principales: Nishimura, Yuji, Masaki, Katsuhisa, Matsuse, Dai, Yamaguchi, Hiroo, Tanaka, Tatsunori, Matsuo, Eriko, Hayashida, Shotaro, Watanabe, Mitsuru, Matsushita, Takuya, Sadashima, Shoko, Sasagasako, Naokazu, Yamasaki, Ryo, Isobe, Noriko, Iwaki, Toru, Kira, Jun‐ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154368/
https://www.ncbi.nlm.nih.gov/pubmed/36368713
http://dx.doi.org/10.1111/bpa.13131

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