Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells

Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities in several pathologies including cancer. When the GSDMB pore-forming N-terminal domain is released by Granzyme-A cleavage, it provokes c...

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Detalles Bibliográficos
Autores principales: Oltra, Sara S., Colomo, Sara, Sin, Laura, Pérez-López, María, Lázaro, Sara, Molina-Crespo, Angela, Choi, Kyoung-Han, Ros-Pardo, David, Martínez, Lidia, Morales, Saleta, González-Paramos, Cristina, Orantes, Alba, Soriano, Mario, Hernández, Alberto, Lluch, Ana, Rojo, Federico, Albanell, Joan, Gómez-Puertas, Paulino, Ko, Jae-Kyun, Sarrió, David, Moreno-Bueno, Gema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154425/
https://www.ncbi.nlm.nih.gov/pubmed/36899106
http://dx.doi.org/10.1038/s41418-023-01143-y

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