Cargando…
Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
Bone regeneration is one of the most well-known fields in tissue regeneration. The major focus concerns polymeric/ceramic composite scaffolds. In this work, several composite scaffolds based on chitosan (CH), with low and high molecular weights, and different concentrations of ceramics like mesoporo...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154456/ https://www.ncbi.nlm.nih.gov/pubmed/36757613 http://dx.doi.org/10.1007/s40204-023-00217-x |
_version_ | 1785036125478322176 |
---|---|
author | Pádua, Ana Sofia Figueiredo, Lígia Silva, Jorge Carvalho Borges, João Paulo |
author_facet | Pádua, Ana Sofia Figueiredo, Lígia Silva, Jorge Carvalho Borges, João Paulo |
author_sort | Pádua, Ana Sofia |
collection | PubMed |
description | Bone regeneration is one of the most well-known fields in tissue regeneration. The major focus concerns polymeric/ceramic composite scaffolds. In this work, several composite scaffolds based on chitosan (CH), with low and high molecular weights, and different concentrations of ceramics like mesoporous bioactive glass (MBG), mesoporous hydroxyapatite (MHAp) and both MBG and MHAp (MC) were produced by lyophilization. The purpose is to identify the best combination regarding optimal morphology and properties. The tests of the scaffolds present a highly porous structure with interconnected pores. The compression modulus increases with ceramic concentration in the scaffolds. Furthermore, the 75%MBG (835 ± 160 kPa) and 50%MC (1070 ± 205 kPa) samples are the ones that mostly enhance increases in mechanical properties. The swelling capacity increases with MBG and MC, respectively, to 700% and 900% and decreases to 400% when MHAp concentration increases. All scaffolds are non-cytotoxic at 12.5 mg/mL. The CHL scaffolds improve cell adhesion and proliferation compared to CHH, and the MC scaffold samples, show better results than those produced with just MBG or MHAp. The composite scaffolds of chitosan with MBG and MHAp, have revealed to be the best combination due to their enhanced performance in bone tissue engineering. |
format | Online Article Text |
id | pubmed-10154456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-101544562023-05-04 Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass Pádua, Ana Sofia Figueiredo, Lígia Silva, Jorge Carvalho Borges, João Paulo Prog Biomater Original Research Bone regeneration is one of the most well-known fields in tissue regeneration. The major focus concerns polymeric/ceramic composite scaffolds. In this work, several composite scaffolds based on chitosan (CH), with low and high molecular weights, and different concentrations of ceramics like mesoporous bioactive glass (MBG), mesoporous hydroxyapatite (MHAp) and both MBG and MHAp (MC) were produced by lyophilization. The purpose is to identify the best combination regarding optimal morphology and properties. The tests of the scaffolds present a highly porous structure with interconnected pores. The compression modulus increases with ceramic concentration in the scaffolds. Furthermore, the 75%MBG (835 ± 160 kPa) and 50%MC (1070 ± 205 kPa) samples are the ones that mostly enhance increases in mechanical properties. The swelling capacity increases with MBG and MC, respectively, to 700% and 900% and decreases to 400% when MHAp concentration increases. All scaffolds are non-cytotoxic at 12.5 mg/mL. The CHL scaffolds improve cell adhesion and proliferation compared to CHH, and the MC scaffold samples, show better results than those produced with just MBG or MHAp. The composite scaffolds of chitosan with MBG and MHAp, have revealed to be the best combination due to their enhanced performance in bone tissue engineering. Springer Berlin Heidelberg 2023-02-09 /pmc/articles/PMC10154456/ /pubmed/36757613 http://dx.doi.org/10.1007/s40204-023-00217-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Pádua, Ana Sofia Figueiredo, Lígia Silva, Jorge Carvalho Borges, João Paulo Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
title | Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
title_full | Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
title_fullStr | Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
title_full_unstemmed | Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
title_short | Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
title_sort | chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154456/ https://www.ncbi.nlm.nih.gov/pubmed/36757613 http://dx.doi.org/10.1007/s40204-023-00217-x |
work_keys_str_mv | AT paduaanasofia chitosanscaffoldswithmesoporoushydroxyapatiteandmesoporousbioactiveglass AT figueiredoligia chitosanscaffoldswithmesoporoushydroxyapatiteandmesoporousbioactiveglass AT silvajorgecarvalho chitosanscaffoldswithmesoporoushydroxyapatiteandmesoporousbioactiveglass AT borgesjoaopaulo chitosanscaffoldswithmesoporoushydroxyapatiteandmesoporousbioactiveglass |