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Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges
Alzheimer’s disease is a severe, highly disabling neurodegenerative disease, clinically characterized by a progressive decline in cognitive functions, and is the most common form of dementia in the elderly. For decades, the search for disease-modifying therapies has focused on the two main Alzheimer...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154491/ https://www.ncbi.nlm.nih.gov/pubmed/36751774 http://dx.doi.org/10.4103/1673-5374.361546 |
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author | Gonçalves, Renata Guedes de Jesus Vasques, Juliana Ferreira da Silva-Junior, Almir Jordão Gubert, Fernanda Mendez-Otero, Rosalia |
author_facet | Gonçalves, Renata Guedes de Jesus Vasques, Juliana Ferreira da Silva-Junior, Almir Jordão Gubert, Fernanda Mendez-Otero, Rosalia |
author_sort | Gonçalves, Renata Guedes de Jesus |
collection | PubMed |
description | Alzheimer’s disease is a severe, highly disabling neurodegenerative disease, clinically characterized by a progressive decline in cognitive functions, and is the most common form of dementia in the elderly. For decades, the search for disease-modifying therapies has focused on the two main Alzheimer’s disease histopathological hallmarks, seeking to prevent, mitigate, or clear the formation of extracellular aggregates of β-amyloid peptide and intracellular neurofibrillary tangles of tau protein, although without clinical success. Mesenchymal stem cell-based therapy has emerged as a promising alternative for the treatment of Alzheimer’s disease, especially because it also targets other crucial players in the pathogenesis of the disease, such as neuroinflammation, synaptic dysfunction/loss, oxidative stress, and impaired neurogenesis. Herein, we review current knowledge of the therapeutic potential of mesenchymal stem cells and their extracellular vesicles for Alzheimer’s disease, discussing the most recent findings in both preclinical and clinical trials as well as how advanced technologies have helped to overcome some limitations and contributed to stimulate the development of more effective treatments. |
format | Online Article Text |
id | pubmed-10154491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-101544912023-05-04 Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges Gonçalves, Renata Guedes de Jesus Vasques, Juliana Ferreira da Silva-Junior, Almir Jordão Gubert, Fernanda Mendez-Otero, Rosalia Neural Regen Res Review Alzheimer’s disease is a severe, highly disabling neurodegenerative disease, clinically characterized by a progressive decline in cognitive functions, and is the most common form of dementia in the elderly. For decades, the search for disease-modifying therapies has focused on the two main Alzheimer’s disease histopathological hallmarks, seeking to prevent, mitigate, or clear the formation of extracellular aggregates of β-amyloid peptide and intracellular neurofibrillary tangles of tau protein, although without clinical success. Mesenchymal stem cell-based therapy has emerged as a promising alternative for the treatment of Alzheimer’s disease, especially because it also targets other crucial players in the pathogenesis of the disease, such as neuroinflammation, synaptic dysfunction/loss, oxidative stress, and impaired neurogenesis. Herein, we review current knowledge of the therapeutic potential of mesenchymal stem cells and their extracellular vesicles for Alzheimer’s disease, discussing the most recent findings in both preclinical and clinical trials as well as how advanced technologies have helped to overcome some limitations and contributed to stimulate the development of more effective treatments. Wolters Kluwer - Medknow 2022-11-25 /pmc/articles/PMC10154491/ /pubmed/36751774 http://dx.doi.org/10.4103/1673-5374.361546 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Gonçalves, Renata Guedes de Jesus Vasques, Juliana Ferreira da Silva-Junior, Almir Jordão Gubert, Fernanda Mendez-Otero, Rosalia Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges |
title | Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges |
title_full | Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges |
title_fullStr | Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges |
title_full_unstemmed | Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges |
title_short | Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer’s disease: progress, advantages, and challenges |
title_sort | mesenchymal stem cell- and extracellular vesicle-based therapies for alzheimer’s disease: progress, advantages, and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154491/ https://www.ncbi.nlm.nih.gov/pubmed/36751774 http://dx.doi.org/10.4103/1673-5374.361546 |
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