Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation

Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of e...

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Autores principales: Bandres, Maria F., Gomes, Jefferson L., Moreno Romero, Gerson N., Twyman, Avery R., McPherson, Jacob Graves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154513/
https://www.ncbi.nlm.nih.gov/pubmed/37152244
http://dx.doi.org/10.3389/fresc.2023.1135593
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author Bandres, Maria F.
Gomes, Jefferson L.
Moreno Romero, Gerson N.
Twyman, Avery R.
McPherson, Jacob Graves
author_facet Bandres, Maria F.
Gomes, Jefferson L.
Moreno Romero, Gerson N.
Twyman, Avery R.
McPherson, Jacob Graves
author_sort Bandres, Maria F.
collection PubMed
description Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of emerging spinal stimulation-based therapies focus on a single issue: locomotor rehabilitation. Despite the enormous potential of these translational advances to transform the lives of people living with spinal cord injury, meaningful recovery in other domains deemed critical priorities remains lacking. Here, we highlight the importance of considering the diverse patterns of neural transmission that underlie clinically similar presentations when developing spinal stimulation-based therapies. We also motivate advancement of multi-modal rehabilitation paradigms, which leverage the dense interconnectivity of sensorimotor spinal networks and the unique ability of electrical stimulation to modulate these networks to facilitate and guide simultaneous rehabilitation across domains.
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spelling pubmed-101545132023-05-04 Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation Bandres, Maria F. Gomes, Jefferson L. Moreno Romero, Gerson N. Twyman, Avery R. McPherson, Jacob Graves Front Rehabil Sci Rehabilitation Sciences Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of emerging spinal stimulation-based therapies focus on a single issue: locomotor rehabilitation. Despite the enormous potential of these translational advances to transform the lives of people living with spinal cord injury, meaningful recovery in other domains deemed critical priorities remains lacking. Here, we highlight the importance of considering the diverse patterns of neural transmission that underlie clinically similar presentations when developing spinal stimulation-based therapies. We also motivate advancement of multi-modal rehabilitation paradigms, which leverage the dense interconnectivity of sensorimotor spinal networks and the unique ability of electrical stimulation to modulate these networks to facilitate and guide simultaneous rehabilitation across domains. Frontiers Media S.A. 2023-04-19 /pmc/articles/PMC10154513/ /pubmed/37152244 http://dx.doi.org/10.3389/fresc.2023.1135593 Text en © 2023 Bandres, Gomes, Moreno Romero, Twyman and McPherson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Rehabilitation Sciences
Bandres, Maria F.
Gomes, Jefferson L.
Moreno Romero, Gerson N.
Twyman, Avery R.
McPherson, Jacob Graves
Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation
title Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation
title_full Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation
title_fullStr Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation
title_full_unstemmed Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation
title_short Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation
title_sort precision neuromodulation: promises and challenges of spinal stimulation for multi-modal rehabilitation
topic Rehabilitation Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154513/
https://www.ncbi.nlm.nih.gov/pubmed/37152244
http://dx.doi.org/10.3389/fresc.2023.1135593
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