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Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants
INTRODUCTION: SARS-CoV-2 is the etiologic agent of coronavirus disease 2019 (COVID-19). Questions remain regarding correlates of risk and immune protection against COVID-19. METHODS: We prospectively enrolled 200 participants with a high risk of SARS-CoV-2 occupational exposure at a U.S. medical cen...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154521/ https://www.ncbi.nlm.nih.gov/pubmed/37153624 http://dx.doi.org/10.3389/fimmu.2023.1139915 |
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author | Jenkins, Meagan M. Phan Tran, Donna Flores, Evelyn A. Kupferwasser, Deborah Pickering, Harry Zheng, Ying Gjertson, David W. Ross, Ted M. Schaenman, Joanna M. Miller, Loren G. Yeaman, Michael R. Reed, Elaine F. |
author_facet | Jenkins, Meagan M. Phan Tran, Donna Flores, Evelyn A. Kupferwasser, Deborah Pickering, Harry Zheng, Ying Gjertson, David W. Ross, Ted M. Schaenman, Joanna M. Miller, Loren G. Yeaman, Michael R. Reed, Elaine F. |
author_sort | Jenkins, Meagan M. |
collection | PubMed |
description | INTRODUCTION: SARS-CoV-2 is the etiologic agent of coronavirus disease 2019 (COVID-19). Questions remain regarding correlates of risk and immune protection against COVID-19. METHODS: We prospectively enrolled 200 participants with a high risk of SARS-CoV-2 occupational exposure at a U.S. medical center between December 2020 and April 2022. Participant exposure risks, vaccination/infection status, and symptoms were followed longitudinally at 3, 6, and 12 months, with blood and saliva collection. Serological response to the SARS-CoV-2 spike holoprotein (S), receptor binding domain (RBD) and nucleocapsid proteins (NP) were quantified by ELISA assay. RESULTS: Based on serology, 40 of 200 (20%) participants were infected. Healthcare and non-healthcare occupations had equivalent infection incidence. Only 79.5% of infected participants seroconverted for NP following infection, and 11.5% were unaware they had been infected. The antibody response to S was greater than to RBD. Hispanic ethnicity was associated with 2-fold greater incidence of infection despite vaccination in this cohort. DISCUSSION: Overall, our findings demonstrate: 1) variability in the antibody response to SARS-CoV-2 infection despite similar exposure risk; 2) the concentration of binding antibody to the SARS-CoV-2 S or RBD proteins is not directly correlated with protection against infection in vaccinated individuals; and 3) determinants of infection risk include Hispanic ethnicity despite vaccination and similar occupational exposure. |
format | Online Article Text |
id | pubmed-10154521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101545212023-05-04 Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants Jenkins, Meagan M. Phan Tran, Donna Flores, Evelyn A. Kupferwasser, Deborah Pickering, Harry Zheng, Ying Gjertson, David W. Ross, Ted M. Schaenman, Joanna M. Miller, Loren G. Yeaman, Michael R. Reed, Elaine F. Front Immunol Immunology INTRODUCTION: SARS-CoV-2 is the etiologic agent of coronavirus disease 2019 (COVID-19). Questions remain regarding correlates of risk and immune protection against COVID-19. METHODS: We prospectively enrolled 200 participants with a high risk of SARS-CoV-2 occupational exposure at a U.S. medical center between December 2020 and April 2022. Participant exposure risks, vaccination/infection status, and symptoms were followed longitudinally at 3, 6, and 12 months, with blood and saliva collection. Serological response to the SARS-CoV-2 spike holoprotein (S), receptor binding domain (RBD) and nucleocapsid proteins (NP) were quantified by ELISA assay. RESULTS: Based on serology, 40 of 200 (20%) participants were infected. Healthcare and non-healthcare occupations had equivalent infection incidence. Only 79.5% of infected participants seroconverted for NP following infection, and 11.5% were unaware they had been infected. The antibody response to S was greater than to RBD. Hispanic ethnicity was associated with 2-fold greater incidence of infection despite vaccination in this cohort. DISCUSSION: Overall, our findings demonstrate: 1) variability in the antibody response to SARS-CoV-2 infection despite similar exposure risk; 2) the concentration of binding antibody to the SARS-CoV-2 S or RBD proteins is not directly correlated with protection against infection in vaccinated individuals; and 3) determinants of infection risk include Hispanic ethnicity despite vaccination and similar occupational exposure. Frontiers Media S.A. 2023-04-19 /pmc/articles/PMC10154521/ /pubmed/37153624 http://dx.doi.org/10.3389/fimmu.2023.1139915 Text en Copyright © 2023 Jenkins, Phan Tran, Flores, Kupferwasser, Pickering, Zheng, Gjertson, Ross, Schaenman, Miller, Yeaman and Reed https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jenkins, Meagan M. Phan Tran, Donna Flores, Evelyn A. Kupferwasser, Deborah Pickering, Harry Zheng, Ying Gjertson, David W. Ross, Ted M. Schaenman, Joanna M. Miller, Loren G. Yeaman, Michael R. Reed, Elaine F. Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants |
title | Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants |
title_full | Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants |
title_fullStr | Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants |
title_full_unstemmed | Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants |
title_short | Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants |
title_sort | longitudinal analysis of sars-cov-2 infection and vaccination in the la-sparta cohort reveals increased risk of infection in vaccinated hispanic participants |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154521/ https://www.ncbi.nlm.nih.gov/pubmed/37153624 http://dx.doi.org/10.3389/fimmu.2023.1139915 |
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