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Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer

The toxic effects of chemotherapy drugs on normal tissues are still a major limiting factor in cancer treatment. In this paper, we report a metal-organic framework (Zn-Co ZIF) with chitosan-coated outer layer as a carrier for the drug adriamycin hydrochloride (DOX), a treatment for liver cancer, as...

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Autores principales: Yang, Congling, Tiwari, Santosh K., Guo, Lianshan, An, Guanghui, Zheng, Heming, Huang, JianFeng, Jiang, Li, Bai, Zhihao, Zhu, Yanqiu, Wang, Nannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154549/
https://www.ncbi.nlm.nih.gov/pubmed/37152005
http://dx.doi.org/10.3389/fonc.2023.1110909
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author Yang, Congling
Tiwari, Santosh K.
Guo, Lianshan
An, Guanghui
Zheng, Heming
Huang, JianFeng
Jiang, Li
Bai, Zhihao
Zhu, Yanqiu
Wang, Nannan
author_facet Yang, Congling
Tiwari, Santosh K.
Guo, Lianshan
An, Guanghui
Zheng, Heming
Huang, JianFeng
Jiang, Li
Bai, Zhihao
Zhu, Yanqiu
Wang, Nannan
author_sort Yang, Congling
collection PubMed
description The toxic effects of chemotherapy drugs on normal tissues are still a major limiting factor in cancer treatment. In this paper, we report a metal-organic framework (Zn-Co ZIF) with chitosan-coated outer layer as a carrier for the drug adriamycin hydrochloride (DOX), a treatment for liver cancer, as a novel anti-cancer nanodrug-enhanced carrier. Gold nanoparticles, a good photothermal conversion agent, were combined with the target SH-RGD during surface functionalisation to prepare Zn-Co ZIF@DOX-CS-Au-RGD (ZD-CAR), a nanoplatform with good photothermal conversion properties and targeting for combined liver cancer therapy. ZD-CAR was developed after RGD accurately targeted the tumour and entered the tumour microenvironment (TME), it cleaves and releases the liver cancer therapeutic agent (DOX) in a weak acidic environment to effectively kill tumour cells. The metal skeleton cleavage releases Co(2+), which catalyzes the production of oxygen from H(2)O(2) to alleviate the tumour hypoxic environment. The dissolved oxygen could reach 14 mg/L after adding 80 mg/mL of ZD-CAR. Meanwhile, gold nanoparticles could convert light energy into heat energy under 808 NIR irradiation to induce local superheating and kill tumour cells. In summary, this study developed a nanoplatform that combines chemo-photothermal-targeted therapy. It has shown good therapeutic effeciency in cellular experiments and performance tests and has promising applications in anti-cancer therapy.
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spelling pubmed-101545492023-05-04 Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer Yang, Congling Tiwari, Santosh K. Guo, Lianshan An, Guanghui Zheng, Heming Huang, JianFeng Jiang, Li Bai, Zhihao Zhu, Yanqiu Wang, Nannan Front Oncol Oncology The toxic effects of chemotherapy drugs on normal tissues are still a major limiting factor in cancer treatment. In this paper, we report a metal-organic framework (Zn-Co ZIF) with chitosan-coated outer layer as a carrier for the drug adriamycin hydrochloride (DOX), a treatment for liver cancer, as a novel anti-cancer nanodrug-enhanced carrier. Gold nanoparticles, a good photothermal conversion agent, were combined with the target SH-RGD during surface functionalisation to prepare Zn-Co ZIF@DOX-CS-Au-RGD (ZD-CAR), a nanoplatform with good photothermal conversion properties and targeting for combined liver cancer therapy. ZD-CAR was developed after RGD accurately targeted the tumour and entered the tumour microenvironment (TME), it cleaves and releases the liver cancer therapeutic agent (DOX) in a weak acidic environment to effectively kill tumour cells. The metal skeleton cleavage releases Co(2+), which catalyzes the production of oxygen from H(2)O(2) to alleviate the tumour hypoxic environment. The dissolved oxygen could reach 14 mg/L after adding 80 mg/mL of ZD-CAR. Meanwhile, gold nanoparticles could convert light energy into heat energy under 808 NIR irradiation to induce local superheating and kill tumour cells. In summary, this study developed a nanoplatform that combines chemo-photothermal-targeted therapy. It has shown good therapeutic effeciency in cellular experiments and performance tests and has promising applications in anti-cancer therapy. Frontiers Media S.A. 2023-04-19 /pmc/articles/PMC10154549/ /pubmed/37152005 http://dx.doi.org/10.3389/fonc.2023.1110909 Text en Copyright © 2023 Yang, Tiwari, Guo, An, Zheng, Huang, Jiang, Bai, Zhu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Congling
Tiwari, Santosh K.
Guo, Lianshan
An, Guanghui
Zheng, Heming
Huang, JianFeng
Jiang, Li
Bai, Zhihao
Zhu, Yanqiu
Wang, Nannan
Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
title Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
title_full Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
title_fullStr Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
title_full_unstemmed Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
title_short Zn-Co metal organic frameworks coated with chitosand and Au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
title_sort zn-co metal organic frameworks coated with chitosand and au nanoparticles for chemo-photothermal-targeted combination therapy of liver cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154549/
https://www.ncbi.nlm.nih.gov/pubmed/37152005
http://dx.doi.org/10.3389/fonc.2023.1110909
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