The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types, including prostate cancer (PCa). Both KDM1A and...

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Detalles Bibliográficos
Autores principales: Metzler, Veronika M., de Brot, Simone, Haigh, Daisy B., Woodcock, Corinne L., Lothion-Roy, Jennifer, Harris, Anna E., Nilsson, Emeli M., Ntekim, Atara, Persson, Jenny L., Robinson, Brian D., Khani, Francesca, Laursen, Kristian B., Gudas, Lorraine J., Toss, Michael S., Madhusudan, Srinivasan, Rakha, Emad, Heery, David M., Rutland, Catrin S., Mongan, Nigel P., Jeyapalan, Jennie N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154691/
https://www.ncbi.nlm.nih.gov/pubmed/37152294
http://dx.doi.org/10.3389/fcell.2023.1116424

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