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UXT at the crossroads of cell death, immunity and neurodegenerative diseases

The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the reg...

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Autores principales: Han, Pengzhe, Mo, Shaojian, Wang, Zhengwang, Xu, Jiale, Fu, Xifeng, Tian, Yanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154696/
https://www.ncbi.nlm.nih.gov/pubmed/37152054
http://dx.doi.org/10.3389/fonc.2023.1179947
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author Han, Pengzhe
Mo, Shaojian
Wang, Zhengwang
Xu, Jiale
Fu, Xifeng
Tian, Yanzhang
author_facet Han, Pengzhe
Mo, Shaojian
Wang, Zhengwang
Xu, Jiale
Fu, Xifeng
Tian, Yanzhang
author_sort Han, Pengzhe
collection PubMed
description The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the regulation of cell metabolism, thereby affecting tumor progression. UXT also maintains immune homeostasis and reduces proteotoxicity in neuro-degenerative diseases through selective autophagy and molecular chaperones. Herein, we review and further elucidate the mechanisms by which UXT affects the regulation of cell death, maintenance of immune homeostasis, and neurodegenerative diseases and discuss the possible UXT involvement in the regulation of ferroptosis and immunogenic cell death, and targeting it to improve cancer treatment outcomes by regulating cell death and immune surveillance.
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spelling pubmed-101546962023-05-04 UXT at the crossroads of cell death, immunity and neurodegenerative diseases Han, Pengzhe Mo, Shaojian Wang, Zhengwang Xu, Jiale Fu, Xifeng Tian, Yanzhang Front Oncol Oncology The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the regulation of cell metabolism, thereby affecting tumor progression. UXT also maintains immune homeostasis and reduces proteotoxicity in neuro-degenerative diseases through selective autophagy and molecular chaperones. Herein, we review and further elucidate the mechanisms by which UXT affects the regulation of cell death, maintenance of immune homeostasis, and neurodegenerative diseases and discuss the possible UXT involvement in the regulation of ferroptosis and immunogenic cell death, and targeting it to improve cancer treatment outcomes by regulating cell death and immune surveillance. Frontiers Media S.A. 2023-04-19 /pmc/articles/PMC10154696/ /pubmed/37152054 http://dx.doi.org/10.3389/fonc.2023.1179947 Text en Copyright © 2023 Han, Mo, Wang, Xu, Fu and Tian https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Han, Pengzhe
Mo, Shaojian
Wang, Zhengwang
Xu, Jiale
Fu, Xifeng
Tian, Yanzhang
UXT at the crossroads of cell death, immunity and neurodegenerative diseases
title UXT at the crossroads of cell death, immunity and neurodegenerative diseases
title_full UXT at the crossroads of cell death, immunity and neurodegenerative diseases
title_fullStr UXT at the crossroads of cell death, immunity and neurodegenerative diseases
title_full_unstemmed UXT at the crossroads of cell death, immunity and neurodegenerative diseases
title_short UXT at the crossroads of cell death, immunity and neurodegenerative diseases
title_sort uxt at the crossroads of cell death, immunity and neurodegenerative diseases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154696/
https://www.ncbi.nlm.nih.gov/pubmed/37152054
http://dx.doi.org/10.3389/fonc.2023.1179947
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