Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain

The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have developed a high-affinity human monoclonal...

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Detalles Bibliográficos
Autores principales: Romanenko, Ya. O., Silkina, M. V., Kartseva, A. S., Marin, M. A., Shkuratova, M. A., Makarova, M. A., Ryabko, A. K., Konyshkova, D. A., Zeninskaya, N. A., Khlyntseva, A. E., Shemyakin, I. G., Firstova, V. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154778/
https://www.ncbi.nlm.nih.gov/pubmed/37153507
http://dx.doi.org/10.32607/actanaturae.11849
Descripción
Sumario:The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have developed a high-affinity human monoclonal antibody, called C6D7-RBD, which is specific to the S protein receptor-binding domain (RBD) from the SARS-CoV-2 Wuhan-Hu-1 strain and exhibits virus-neutralizing activity in a test with recombinant antigens: angiotensin-converting enzyme 2 (ACE2) and RBD.

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