Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain

The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have developed a high-affinity human monoclonal...

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Autores principales: Romanenko, Ya. O., Silkina, M. V., Kartseva, A. S., Marin, M. A., Shkuratova, M. A., Makarova, M. A., Ryabko, A. K., Konyshkova, D. A., Zeninskaya, N. A., Khlyntseva, A. E., Shemyakin, I. G., Firstova, V. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154778/
https://www.ncbi.nlm.nih.gov/pubmed/37153507
http://dx.doi.org/10.32607/actanaturae.11849
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author Romanenko, Ya. O.
Silkina, M. V.
Kartseva, A. S.
Marin, M. A.
Shkuratova, M. A.
Makarova, M. A.
Ryabko, A. K.
Konyshkova, D. A.
Zeninskaya, N. A.
Khlyntseva, A. E.
Shemyakin, I. G.
Firstova, V. V.
author_facet Romanenko, Ya. O.
Silkina, M. V.
Kartseva, A. S.
Marin, M. A.
Shkuratova, M. A.
Makarova, M. A.
Ryabko, A. K.
Konyshkova, D. A.
Zeninskaya, N. A.
Khlyntseva, A. E.
Shemyakin, I. G.
Firstova, V. V.
author_sort Romanenko, Ya. O.
collection PubMed
description The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have developed a high-affinity human monoclonal antibody, called C6D7-RBD, which is specific to the S protein receptor-binding domain (RBD) from the SARS-CoV-2 Wuhan-Hu-1 strain and exhibits virus-neutralizing activity in a test with recombinant antigens: angiotensin-converting enzyme 2 (ACE2) and RBD.
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spelling pubmed-101547782023-05-04 Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain Romanenko, Ya. O. Silkina, M. V. Kartseva, A. S. Marin, M. A. Shkuratova, M. A. Makarova, M. A. Ryabko, A. K. Konyshkova, D. A. Zeninskaya, N. A. Khlyntseva, A. E. Shemyakin, I. G. Firstova, V. V. Acta Naturae Research Article The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have developed a high-affinity human monoclonal antibody, called C6D7-RBD, which is specific to the S protein receptor-binding domain (RBD) from the SARS-CoV-2 Wuhan-Hu-1 strain and exhibits virus-neutralizing activity in a test with recombinant antigens: angiotensin-converting enzyme 2 (ACE2) and RBD. A.I. Gordeyev 2023 /pmc/articles/PMC10154778/ /pubmed/37153507 http://dx.doi.org/10.32607/actanaturae.11849 Text en Copyright ® 2023 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Romanenko, Ya. O.
Silkina, M. V.
Kartseva, A. S.
Marin, M. A.
Shkuratova, M. A.
Makarova, M. A.
Ryabko, A. K.
Konyshkova, D. A.
Zeninskaya, N. A.
Khlyntseva, A. E.
Shemyakin, I. G.
Firstova, V. V.
Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
title Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
title_full Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
title_fullStr Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
title_full_unstemmed Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
title_short Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
title_sort characterization of the c6d7-rbd human monoclonal antibody specific to the sars-cov-2 s protein receptor-binding domain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154778/
https://www.ncbi.nlm.nih.gov/pubmed/37153507
http://dx.doi.org/10.32607/actanaturae.11849
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