Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a(+)CD207(+) dendritic cells (DCs). SIRPα is a transmembrane protein highly expressed in myeloid cells such as DCs and macrophages. Here we...

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Detalles Bibliográficos
Autores principales: Okamoto, Takeshi, Murata, Yoji, Hasegawa, Daiichiro, Yoshida, Makiko, Tanaka, Daisuke, Ueda, Takashi, Hazama, Daisuke, Oduori, Okechi S., Komori, Satomi, Takai, Tomoko, Saito, Yasuyuki, Kotani, Takenori, Kosaka, Yoshiyuki, Maniwa, Yoshimasa, Matozaki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154843/
https://www.ncbi.nlm.nih.gov/pubmed/36788737
http://dx.doi.org/10.1111/cas.15758

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