Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor

Constitutive activation of the mitogen‐activated protein kinase (MAPK) signaling pathway is essential for tumorigenesis of pancreatic ductal adenocarcinoma (PDAC). To date, however, almost all clinical trials of inhibitor targeting this pathway have failed to improve the outcome of patients with PDA...

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Detalles Bibliográficos
Autores principales: Amada, Kohei, Hijiya, Naoki, Ikarimoto, Sawa, Yanagihara, Kazuyoshi, Hanada, Toshikatsu, Hidano, Shinya, Kurogi, Shusaku, Tsukamoto, Yoshiyuki, Nakada, Chisato, Kinoshita, Keisuke, Hirashita, Yuka, Uchida, Tomohisa, Shin, Toshitaka, Yada, Kazuhiro, Hirashita, Teijiro, Kobayashi, Takashi, Murakami, Kazunari, Inomata, Masafumi, Shirao, Kuniaki, Aoki, Masahiro, Takekawa, Mutsuhiro, Moriyama, Masatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154874/
https://www.ncbi.nlm.nih.gov/pubmed/36694355
http://dx.doi.org/10.1111/cas.15735

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