Cargando…

Frizzled‐7‐targeting antibody (SHH002‐hu1) potently suppresses non–small‐cell lung cancer via Wnt/β‐catenin signaling

Non–small‐cell lung cancer (NSCLC) is one of the deadliest cancers worldwide, and metastasis is considered one of the leading causes of treatment failure in NSCLC. Wnt/β‐catenin signaling is crucially involved in epithelial–mesenchymal transition (EMT), a crucial factor in promoting metastasis, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Kanghua, Mao, Shuyang, Li, Xingxing, Zhao, Huijie, Wang, Jingyi, Wang, Chenyue, Wu, Lisha, Zhang, Kunchi, Yang, Hao, Jin, Mingming, Zhou, Zhaoli, Wang, Jin, Huang, Gang, Xie, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154902/ https://www.ncbi.nlm.nih.gov/pubmed/36625184 http://dx.doi.org/10.1111/cas.15721

Ejemplares similares

A novel humanized Frizzled-7-targeting antibody enhances antitumor effects of Bevacizumab against triple-negative breast cancer via blocking Wnt/β-catenin signaling pathway
por: Xie, Wei, et al.
Publicado: (2021)

Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
por: Hendaoui, Ismaïl, et al.
Publicado: (2012)

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
por: Kim, Hyun-Taek, et al.
Publicado: (2017)

Correction: Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
por: Hendaoui, Ismaïl, et al.
Publicado: (2012)

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
por: Tao, Yuyong, et al.
Publicado: (2019)

Aberrant Cholesterol Metabolism and Wnt/β‐Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth
por: Zheng, Shaoqin, et al.
Publicado: (2022)

A Cryptic Frizzled Module in Cell Surface Collagen 18 Inhibits Wnt/β−Catenin Signaling
por: Quélard, Delphine, et al.
Publicado: (2008)

Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway
por: Wei, Wen-Ying, et al.
Publicado: (2020)

Frizzled 7 Expression Is Positively Regulated by SIRT1 and β-Catenin in Breast Cancer Cells
por: Simmons, Glenn E., et al.
Publicado: (2014)

The Levels of Wnt5a and Its Receptors Frizzled5 and Frizzled2 as Immunohistochemical Biomarkers of Severity of Psoriasis
por: Ning, Xiaoying, et al.
Publicado: (2021)

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling
por: Wheeler, David S., et al.
Publicado: (2010)

Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors
por: Schweizer, Liang, et al.
Publicado: (2003)

Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis
por: Aurrekoetxea, Maitane, et al.
Publicado: (2016)

Frizzled7 Promotes Epithelial-to-mesenchymal Transition and Stemness Via Activating Canonical Wnt/β-catenin Pathway in Gastric Cancer
por: Li, Guanman, et al.
Publicado: (2018)

Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly
por: Hyun, Seung Yeob, et al.
Publicado: (2022)

Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo
por: Zhang, Yu, et al.
Publicado: (2022)

WNT/Frizzled-2 Signaling Induces Aggregation and Adhesion among Cardiac Myocytes by Increased Cadherin–β-Catenin Complex
por: Toyofuku, Toshihiko, et al.
Publicado: (2000)

Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling
por: Leung, Carmen Oi-Ning, et al.
Publicado: (2016)

Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis
por: Wu, Fei, et al.
Publicado: (2019)

Deregulation of secreted frizzled-related proteins is associated with aberrant β-catenin activation in the carcinogenesis of oral submucous fibrosis
por: Zhou, Shanghui, et al.
Publicado: (2015)

Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway
por: Zhou, Hui, et al.
Publicado: (2023)

Cardiac hormones are potent inhibitors of secreted frizzled-related protein-3 in human cancer cells
por: SKELTON, WILLIAM P., et al.
Publicado: (2013)

The oncogenic role of Wnt10a in colorectal cancer through activation of canonical Wnt/β-catenin signaling
por: Li, Jinlong, et al.
Publicado: (2019)

Medulloblastoma in China: Clinicopathologic Analyses of SHH, WNT, and Non-SHH/WNT Molecular Subgroups Reveal Different Therapeutic Responses to Adjuvant Chemotherapy
por: Zhang, Zhen-Yu, et al.
Publicado: (2014)

Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways
por: Zins, Karin, et al.
Publicado: (2016)

Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling
por: Swain, Rajeeb Kumar, et al.
Publicado: (2005)

The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5
por: Abdelhamed, Zakia A., et al.
Publicado: (2019)

Antarctic aldehyde dehydrogenase from Flavobacterium PL002 as a potent catalyst for acetaldehyde determination in wine
por: Paun, V. I., et al.
Publicado: (2022)

Correction: Medulloblastoma in China: Clinicopathologic Analyses of SHH, WNT, and Non-SHH/WNT Molecular Subgroups Reveal Different Therapeutic Responses to Adjuvant Chemotherapy
Publicado: (2014)

Correction: Medulloblastoma in China: Clinicopathologic Analyses of SHH, WNT, and Non-SHH/WNT Molecular Subgroups Reveal Different Therapeutic Responses to Adjuvant Chemotherapy
Publicado: (2014)

Wnt Signaling Activates Shh Signaling in Early Postnatal Intervertebral Discs, and Re-Activates Shh Signaling in Old Discs in the Mouse
por: Winkler, Tamara, et al.
Publicado: (2014)

The transcriptional landscape of Shh medulloblastoma
por: Skowron, Patryk, et al.
Publicado: (2021)

A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development
por: Xu, Jingyue, et al.
Publicado: (2016)

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway
por: Rickman, Matthew, et al.
Publicado: (2023)

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
por: Varela-Nallar, Lorena, et al.
Publicado: (2009)

Functional role of the Frizzled linker domain in the Wnt signaling pathway
por: Ko, Seung-Bum, et al.
Publicado: (2022)

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation
por: Teo, Samuel, et al.
Publicado: (2021)

Fibroblast Growth Factors Stimulate Hair Growth through β-Catenin and Shh Expression in C57BL/6 Mice
por: Lin, Wei-hong, et al.
Publicado: (2015)

Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells
por: Okoye, Ujunwa C, et al.
Publicado: (2008)

Shh is out on a limb
por: LeBrasseur, Nicole
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_akd8glb6u4ql6iqb0ruo1521ql