Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome

Tolvaptan is the current standard of treatment for autosomal dominant polycystic kidney disease. It operates by acting on V2 receptors and blocks vasopressin interactions, causing a reduction in the rate of renal cyst growth and preserving kidney function. The current known risks of tolvaptan involv...

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Autores principales: Nguyen, Matthew, Yanny, Beshoy T, Truong, Tai LD, Zhao, Hongyu, Hanna, Ramy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154994/
https://www.ncbi.nlm.nih.gov/pubmed/37151737
http://dx.doi.org/10.1177/2050313X231169841
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author Nguyen, Matthew
Yanny, Beshoy T
Truong, Tai LD
Zhao, Hongyu
Hanna, Ramy
author_facet Nguyen, Matthew
Yanny, Beshoy T
Truong, Tai LD
Zhao, Hongyu
Hanna, Ramy
author_sort Nguyen, Matthew
collection PubMed
description Tolvaptan is the current standard of treatment for autosomal dominant polycystic kidney disease. It operates by acting on V2 receptors and blocks vasopressin interactions, causing a reduction in the rate of renal cyst growth and preserving kidney function. The current known risks of tolvaptan involve a serious liver injury characterized by an elevation in total bilirubin and alanine transaminase and aspartate transaminase levels. In this report, we document a unique liver injury characterized by an elevated bilirubin with normal alanine transaminase and aspartate transaminase levels in a patient who is homozygous for the UGT1A1 consistent with Gilbert syndrome.
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spelling pubmed-101549942023-05-04 Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome Nguyen, Matthew Yanny, Beshoy T Truong, Tai LD Zhao, Hongyu Hanna, Ramy SAGE Open Med Case Rep Case Report Tolvaptan is the current standard of treatment for autosomal dominant polycystic kidney disease. It operates by acting on V2 receptors and blocks vasopressin interactions, causing a reduction in the rate of renal cyst growth and preserving kidney function. The current known risks of tolvaptan involve a serious liver injury characterized by an elevation in total bilirubin and alanine transaminase and aspartate transaminase levels. In this report, we document a unique liver injury characterized by an elevated bilirubin with normal alanine transaminase and aspartate transaminase levels in a patient who is homozygous for the UGT1A1 consistent with Gilbert syndrome. SAGE Publications 2023-04-29 /pmc/articles/PMC10154994/ /pubmed/37151737 http://dx.doi.org/10.1177/2050313X231169841 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Nguyen, Matthew
Yanny, Beshoy T
Truong, Tai LD
Zhao, Hongyu
Hanna, Ramy
Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
title Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
title_full Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
title_fullStr Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
title_full_unstemmed Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
title_short Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
title_sort tolvaptan-induced isolated elevation of bilirubin in a patient with gilbert syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154994/
https://www.ncbi.nlm.nih.gov/pubmed/37151737
http://dx.doi.org/10.1177/2050313X231169841
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