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Enhanced Thermal Stability and Reduced Aggregation in an Antibody Fab Fragment at Elevated Concentrations

[Image: see text] The aggregation of protein therapeutics such as antibodies remains a major challenge in the biopharmaceutical industry. The present study aimed to characterize the impact of the protein concentration on the mechanisms and potential pathways for aggregation, using the antibody Fab f...

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Detalles Bibliográficos
Autores principales:	Zhang, Cheng, Bye, Jordan W., Lui, Lok H., Zhang, Hongyu, Hales, John, Brocchini, Steve, Curtis, Robin A., Dalby, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155210/ https://www.ncbi.nlm.nih.gov/pubmed/37040431 http://dx.doi.org/10.1021/acs.molpharmaceut.3c00081

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