Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

BACKGROUND: Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been shown to increase the structural propensity of these proteins toward self-associat...

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Detalles Bibliográficos
Autores principales: Sampognaro, Paul J., Arya, Shruti, Knudsen, Giselle M., Gunderson, Emma L., Sandoval-Perez, Angelica, Hodul, Molly, Bowles, Kathryn, Craik, Charles S., Jacobson, Matthew P., Kao, Aimee W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155372/
https://www.ncbi.nlm.nih.gov/pubmed/37131250
http://dx.doi.org/10.1186/s13024-023-00621-8

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