PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role

BACKGROUND: Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therapeutic targets. Glycolysis is critical to neutrophil activities during sepsis. Ho...

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Detalles Bibliográficos
Autores principales: Li, Yinjiaozhi, Tan, Ruoming, Li, Ranran, Tian, Rui, Liu, Zhaojun, Wang, Xiaoli, Chen, Erzhen, Pan, Tingting, Qu, Hongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155438/
https://www.ncbi.nlm.nih.gov/pubmed/37131151
http://dx.doi.org/10.1186/s12950-023-00341-2

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