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Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China

The outbreak of the novel coronavirus disease 2019 (COVID-19) has led to significant mental stress for frontline medical workers treating patients with confirmed COVID-19 in China. Psychological stress has an impact on the immune system. The number and percentage of lymphocyte subsets are standard i...

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Autores principales: He, Weijian, Ma, Piyong, Li, Xiuying, Wang, Yali, Zhang, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155498/
https://www.ncbi.nlm.nih.gov/pubmed/37151983
http://dx.doi.org/10.3389/fpsyt.2023.1165614
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author He, Weijian
Ma, Piyong
Li, Xiuying
Wang, Yali
Zhang, Yucheng
author_facet He, Weijian
Ma, Piyong
Li, Xiuying
Wang, Yali
Zhang, Yucheng
author_sort He, Weijian
collection PubMed
description The outbreak of the novel coronavirus disease 2019 (COVID-19) has led to significant mental stress for frontline medical workers treating patients with confirmed COVID-19 in China. Psychological stress has an impact on the immune system. The number and percentage of lymphocyte subsets are standard indicators of cellular immune detection. Here, we reported the differences in CD3, CD4, CD8, CD19, and CD56 lymphocytes between 158 frontline medical workers and 24 controls from medical staffs of the outpatient and emergency departments. We found that frontline medical workers had significantly lower absolute values and percentages of CD19(+) B cells, especially in the female and the aged ≥40 years subgroup. Stratification analysis showed that the absolute values of CD4(+) T cells were significantly lower in the aged <40 years subgroup, while percentages of CD8(+) T cells were lower and percentages of CD56(+) NK cells were higher in the aged ≥40 years subgroup. In summary, this study suggests paying more attention to frontline medical workers’ mental health and immune function, and properly providing them with psychological interventions and measures of care.
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spelling pubmed-101554982023-05-04 Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China He, Weijian Ma, Piyong Li, Xiuying Wang, Yali Zhang, Yucheng Front Psychiatry Psychiatry The outbreak of the novel coronavirus disease 2019 (COVID-19) has led to significant mental stress for frontline medical workers treating patients with confirmed COVID-19 in China. Psychological stress has an impact on the immune system. The number and percentage of lymphocyte subsets are standard indicators of cellular immune detection. Here, we reported the differences in CD3, CD4, CD8, CD19, and CD56 lymphocytes between 158 frontline medical workers and 24 controls from medical staffs of the outpatient and emergency departments. We found that frontline medical workers had significantly lower absolute values and percentages of CD19(+) B cells, especially in the female and the aged ≥40 years subgroup. Stratification analysis showed that the absolute values of CD4(+) T cells were significantly lower in the aged <40 years subgroup, while percentages of CD8(+) T cells were lower and percentages of CD56(+) NK cells were higher in the aged ≥40 years subgroup. In summary, this study suggests paying more attention to frontline medical workers’ mental health and immune function, and properly providing them with psychological interventions and measures of care. Frontiers Media S.A. 2023-04-19 /pmc/articles/PMC10155498/ /pubmed/37151983 http://dx.doi.org/10.3389/fpsyt.2023.1165614 Text en Copyright © 2023 He, Ma, Li, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
He, Weijian
Ma, Piyong
Li, Xiuying
Wang, Yali
Zhang, Yucheng
Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China
title Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China
title_full Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China
title_fullStr Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China
title_full_unstemmed Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China
title_short Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China
title_sort comparison of peripheral blood t, b, and nk lymphocytes between frontline medical workers for treating patients of covid-19 and normal outpatient and emergency medical workers in china
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155498/
https://www.ncbi.nlm.nih.gov/pubmed/37151983
http://dx.doi.org/10.3389/fpsyt.2023.1165614
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