Cargando…

Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review

This study aimed to review the current literature for epidemiology, pathogenesis, clinical spectrum and management of rhino-orbito-cerebral-mucormycosis (ROCM), especially highlighting the association between ROCM and COVID-19 disease and factors resulting in its resurgence during the pandemic. Muco...

Descripción completa

Detalles Bibliográficos
Autores principales: Karkhur, Samendra, Soni, Deepak, Chauhan, Khushboo, Sarkar, Deepayan, Gautam, Megha, Verma, Sunil, Nyodu, Richa, Yadav, Nikita, Sharma, Bhavana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155578/
https://www.ncbi.nlm.nih.gov/pubmed/36588206
http://dx.doi.org/10.4103/ijo.IJO_1219_22
_version_ 1785036360326840320
author Karkhur, Samendra
Soni, Deepak
Chauhan, Khushboo
Sarkar, Deepayan
Gautam, Megha
Verma, Sunil
Nyodu, Richa
Yadav, Nikita
Sharma, Bhavana
author_facet Karkhur, Samendra
Soni, Deepak
Chauhan, Khushboo
Sarkar, Deepayan
Gautam, Megha
Verma, Sunil
Nyodu, Richa
Yadav, Nikita
Sharma, Bhavana
author_sort Karkhur, Samendra
collection PubMed
description This study aimed to review the current literature for epidemiology, pathogenesis, clinical spectrum and management of rhino-orbito-cerebral-mucormycosis (ROCM), especially highlighting the association between ROCM and COVID-19 disease and factors resulting in its resurgence during the pandemic. Mucormycosis is a rare, but an important emerging opportunistic fungal infection, often associated with high morbidity and mortality. ROCM is the commonest and also the most aggressive clinical form occurring in debilitated patients in conjunction with sinus or para-sinus involvement due to the propensity for contiguous spread. Recently ROCM has shown an unprecedented resurgence during the current pandemic. Reports from different parts of the world indicated an increased risk and incidence of ROCM in patients who had required hospital admission and have recovered from moderate-to-severe COVID-19 disease. A majority of mucormycosis cases have been reported from India. The presence of diabetes mellitus (DM) and use of corticosteroids for COVID-19 pneumonia were found to be the key risk factors, resulting in higher mortality. Amidst the ongoing pandemic, with the third wave already having affected most of the world, it becomes imperative to adopt a risk-based approach toward COVID-19 patients predisposed to developing ROCM. This could be based on the most recently published literature and emerging data from centers across the world. The present review intended to elucidate the causes that brought about the current spike in ROCM and the importance of its early detection and management to reduce mortality, loss of eye, and the need for mutilating debridement.
format Online
Article
Text
id pubmed-10155578
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-101555782023-05-04 Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review Karkhur, Samendra Soni, Deepak Chauhan, Khushboo Sarkar, Deepayan Gautam, Megha Verma, Sunil Nyodu, Richa Yadav, Nikita Sharma, Bhavana Indian J Ophthalmol Review Article This study aimed to review the current literature for epidemiology, pathogenesis, clinical spectrum and management of rhino-orbito-cerebral-mucormycosis (ROCM), especially highlighting the association between ROCM and COVID-19 disease and factors resulting in its resurgence during the pandemic. Mucormycosis is a rare, but an important emerging opportunistic fungal infection, often associated with high morbidity and mortality. ROCM is the commonest and also the most aggressive clinical form occurring in debilitated patients in conjunction with sinus or para-sinus involvement due to the propensity for contiguous spread. Recently ROCM has shown an unprecedented resurgence during the current pandemic. Reports from different parts of the world indicated an increased risk and incidence of ROCM in patients who had required hospital admission and have recovered from moderate-to-severe COVID-19 disease. A majority of mucormycosis cases have been reported from India. The presence of diabetes mellitus (DM) and use of corticosteroids for COVID-19 pneumonia were found to be the key risk factors, resulting in higher mortality. Amidst the ongoing pandemic, with the third wave already having affected most of the world, it becomes imperative to adopt a risk-based approach toward COVID-19 patients predisposed to developing ROCM. This could be based on the most recently published literature and emerging data from centers across the world. The present review intended to elucidate the causes that brought about the current spike in ROCM and the importance of its early detection and management to reduce mortality, loss of eye, and the need for mutilating debridement. Wolters Kluwer - Medknow 2023-01 2022-12-30 /pmc/articles/PMC10155578/ /pubmed/36588206 http://dx.doi.org/10.4103/ijo.IJO_1219_22 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Karkhur, Samendra
Soni, Deepak
Chauhan, Khushboo
Sarkar, Deepayan
Gautam, Megha
Verma, Sunil
Nyodu, Richa
Yadav, Nikita
Sharma, Bhavana
Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
title Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
title_full Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
title_fullStr Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
title_full_unstemmed Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
title_short Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
title_sort rhino-orbito-cerebral mucormycosis and its resurgence during covid-19 pandemic: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155578/
https://www.ncbi.nlm.nih.gov/pubmed/36588206
http://dx.doi.org/10.4103/ijo.IJO_1219_22
work_keys_str_mv AT karkhursamendra rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT sonideepak rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT chauhankhushboo rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT sarkardeepayan rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT gautammegha rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT vermasunil rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT nyoduricha rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT yadavnikita rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview
AT sharmabhavana rhinoorbitocerebralmucormycosisanditsresurgenceduringcovid19pandemicareview