Transition-metal-catalyzed domino reactions of strained bicyclic alkenes

This review presents a comprehensive overview of transition-metal-catalyzed domino reactions of strained bicyclic alkenes, including both homo- and heterobicyclic alkenes. These compounds are important synthons in organic synthesis, providing an important platform for the construction of biologicall...

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Detalles Bibliográficos
Autores principales: Pounder, Austin, Neufeld, Eric, Myler, Peter, Tam, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155623/
https://www.ncbi.nlm.nih.gov/pubmed/37153643
http://dx.doi.org/10.3762/bjoc.19.38
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author Pounder, Austin
Neufeld, Eric
Myler, Peter
Tam, William
author_facet Pounder, Austin
Neufeld, Eric
Myler, Peter
Tam, William
author_sort Pounder, Austin
collection PubMed
description This review presents a comprehensive overview of transition-metal-catalyzed domino reactions of strained bicyclic alkenes, including both homo- and heterobicyclic alkenes. These compounds are important synthons in organic synthesis, providing an important platform for the construction of biologically/medicinally significant compounds which bear multiple stereocenters. The review has been divided according to the metal used in the reaction. An overview of the substrate scope, reaction conditions, and their potential applications in organic synthesis is discussed. A comprehensive outlook on the reactivity paradigms of homo- and heterobicyclic alkenes is discussed and should shed light on future directions for further development in this field.
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spelling pubmed-101556232023-05-04 Transition-metal-catalyzed domino reactions of strained bicyclic alkenes Pounder, Austin Neufeld, Eric Myler, Peter Tam, William Beilstein J Org Chem Review This review presents a comprehensive overview of transition-metal-catalyzed domino reactions of strained bicyclic alkenes, including both homo- and heterobicyclic alkenes. These compounds are important synthons in organic synthesis, providing an important platform for the construction of biologically/medicinally significant compounds which bear multiple stereocenters. The review has been divided according to the metal used in the reaction. An overview of the substrate scope, reaction conditions, and their potential applications in organic synthesis is discussed. A comprehensive outlook on the reactivity paradigms of homo- and heterobicyclic alkenes is discussed and should shed light on future directions for further development in this field. Beilstein-Institut 2023-04-24 /pmc/articles/PMC10155623/ /pubmed/37153643 http://dx.doi.org/10.3762/bjoc.19.38 Text en Copyright © 2023, Pounder et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Review
Pounder, Austin
Neufeld, Eric
Myler, Peter
Tam, William
Transition-metal-catalyzed domino reactions of strained bicyclic alkenes
title Transition-metal-catalyzed domino reactions of strained bicyclic alkenes
title_full Transition-metal-catalyzed domino reactions of strained bicyclic alkenes
title_fullStr Transition-metal-catalyzed domino reactions of strained bicyclic alkenes
title_full_unstemmed Transition-metal-catalyzed domino reactions of strained bicyclic alkenes
title_short Transition-metal-catalyzed domino reactions of strained bicyclic alkenes
title_sort transition-metal-catalyzed domino reactions of strained bicyclic alkenes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155623/
https://www.ncbi.nlm.nih.gov/pubmed/37153643
http://dx.doi.org/10.3762/bjoc.19.38
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