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Spatial separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

The Bub1 and BubR1 kinetochore proteins support proper chromosome segregation and mitotic checkpoint activity. Bub1 and BubR1 are paralogs with Bub1 being a kinase, while BubR1 localizes the PP2A-B56 protein phosphatase to kinetochores in humans. Whether this spatial separation of kinase and phospha...

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Detalles Bibliográficos
Autores principales:	Wang, Lei, Kruse, Thomas, López-Méndez, Blanca, Zhang, Yuqing, Song, Chunlin, Zhu, Lei, Li, Bing, Fang, Jing, Lu, Zhimin, Nilsson, Jakob, Zhang, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155811/ https://www.ncbi.nlm.nih.gov/pubmed/36441015 http://dx.doi.org/10.1093/jmcb/mjac062

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