Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome

Deep brain stimulation (DBS) targeting various locations within the globus pallidus internus (GPi) is emerging as a therapeutic option for patients with medically resistant Lesch-Nyhan syndrome. We report our institutional experience with single-electrode DBS in the bilateral posterolateral GPi as a...

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Autores principales: Baird-Daniel, Eliza, Glaser, Adam, Boop, Scott, Durfy, Sharon, Hauptman, Jason S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Pediatric Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155820/
https://www.ncbi.nlm.nih.gov/pubmed/37153246
http://dx.doi.org/10.7759/cureus.37070
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author Baird-Daniel, Eliza
Glaser, Adam
Boop, Scott
Durfy, Sharon
Hauptman, Jason S
author_facet Baird-Daniel, Eliza
Glaser, Adam
Boop, Scott
Durfy, Sharon
Hauptman, Jason S
author_sort Baird-Daniel, Eliza
collection PubMed
description Deep brain stimulation (DBS) targeting various locations within the globus pallidus internus (GPi) is emerging as a therapeutic option for patients with medically resistant Lesch-Nyhan syndrome. We report our institutional experience with single-electrode DBS in the bilateral posterolateral GPi as an effective method for reduction of both dystonia and self-injurious behavior. Two pediatric patients aged six and 14 years underwent implantation of bilateral singular DBS leads in the posterolateral GPi and were followed postoperatively through the programming process and symptomatic improvements. Caregivers reported that after DBS in the posterolateral GPi, these patients experienced decreased self-mutilation behavior and decreased dystonia.
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spelling pubmed-101558202023-05-04 Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome Baird-Daniel, Eliza Glaser, Adam Boop, Scott Durfy, Sharon Hauptman, Jason S Cureus Pediatric Surgery Deep brain stimulation (DBS) targeting various locations within the globus pallidus internus (GPi) is emerging as a therapeutic option for patients with medically resistant Lesch-Nyhan syndrome. We report our institutional experience with single-electrode DBS in the bilateral posterolateral GPi as an effective method for reduction of both dystonia and self-injurious behavior. Two pediatric patients aged six and 14 years underwent implantation of bilateral singular DBS leads in the posterolateral GPi and were followed postoperatively through the programming process and symptomatic improvements. Caregivers reported that after DBS in the posterolateral GPi, these patients experienced decreased self-mutilation behavior and decreased dystonia. Cureus 2023-04-03 /pmc/articles/PMC10155820/ /pubmed/37153246 http://dx.doi.org/10.7759/cureus.37070 Text en Copyright © 2023, Baird-Daniel et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatric Surgery
Baird-Daniel, Eliza
Glaser, Adam
Boop, Scott
Durfy, Sharon
Hauptman, Jason S
Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome
title Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome
title_full Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome
title_fullStr Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome
title_full_unstemmed Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome
title_short Single-Electrode Deep Brain Stimulation of Bilateral Posterolateral Globus Pallidus Internus in Patients With Medically Resistant Lesch-Nyhan Syndrome
title_sort single-electrode deep brain stimulation of bilateral posterolateral globus pallidus internus in patients with medically resistant lesch-nyhan syndrome
topic Pediatric Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155820/
https://www.ncbi.nlm.nih.gov/pubmed/37153246
http://dx.doi.org/10.7759/cureus.37070
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