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Drug complexes: Perspective from Academic Research and Pharmaceutical Market
Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156076/ https://www.ncbi.nlm.nih.gov/pubmed/37138135 http://dx.doi.org/10.1007/s11095-023-03517-w |
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author | Munnangi, Siva Ram Youssef, Ahmed Adel Ali Narala, Nagarjuna Lakkala, Preethi Narala, Sagar Vemula, Sateesh Kumar Repka, Michael |
author_facet | Munnangi, Siva Ram Youssef, Ahmed Adel Ali Narala, Nagarjuna Lakkala, Preethi Narala, Sagar Vemula, Sateesh Kumar Repka, Michael |
author_sort | Munnangi, Siva Ram |
collection | PubMed |
description | Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-10156076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-101560762023-05-09 Drug complexes: Perspective from Academic Research and Pharmaceutical Market Munnangi, Siva Ram Youssef, Ahmed Adel Ali Narala, Nagarjuna Lakkala, Preethi Narala, Sagar Vemula, Sateesh Kumar Repka, Michael Pharm Res Review Paper Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2023-05-03 /pmc/articles/PMC10156076/ /pubmed/37138135 http://dx.doi.org/10.1007/s11095-023-03517-w Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Paper Munnangi, Siva Ram Youssef, Ahmed Adel Ali Narala, Nagarjuna Lakkala, Preethi Narala, Sagar Vemula, Sateesh Kumar Repka, Michael Drug complexes: Perspective from Academic Research and Pharmaceutical Market |
title | Drug complexes: Perspective from Academic Research and Pharmaceutical Market |
title_full | Drug complexes: Perspective from Academic Research and Pharmaceutical Market |
title_fullStr | Drug complexes: Perspective from Academic Research and Pharmaceutical Market |
title_full_unstemmed | Drug complexes: Perspective from Academic Research and Pharmaceutical Market |
title_short | Drug complexes: Perspective from Academic Research and Pharmaceutical Market |
title_sort | drug complexes: perspective from academic research and pharmaceutical market |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156076/ https://www.ncbi.nlm.nih.gov/pubmed/37138135 http://dx.doi.org/10.1007/s11095-023-03517-w |
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