Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis

The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are processed to acetyl-CoA by ATP-citrate lyase (ACLY) and acyl-CoA...

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Detalles Bibliográficos
Autores principales: Izzo, Luke T., Trefely, Sophie, Demetriadou, Christina, Drummond, Jack M., Mizukami, Takuya, Kuprasertkul, Nina, Farria, Aimee T., Nguyen, Phuong T. T., Murali, Nivitha, Reich, Lauren, Kantner, Daniel S., Shaffer, Joshua, Affronti, Hayley, Carrer, Alessandro, Andrews, Andrew, Capell, Brian C., Snyder, Nathaniel W., Wellen, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156126/
https://www.ncbi.nlm.nih.gov/pubmed/37134161
http://dx.doi.org/10.1126/sciadv.adf0115

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