Cargando…

γδ-Enriched CAR-T cell therapy for bone metastatic castrate-resistant prostate cancer

Immune checkpoint blockade has been largely unsuccessful for the treatment of bone metastatic castrate-resistant prostate cancer (mCRPC). Here, we report a combinatorial strategy to treat mCRPC using γδ-enriched chimeric antigen receptor (CAR) T cells and zoledronate (ZOL). In a preclinical murine m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frieling, Jeremy S., Tordesillas, Leticia, Bustos, Xiomar E., Ramello, Maria Cecilia, Bishop, Ryan T., Cianne, Junior E., Snedal, Sebastian A., Li, Tao, Lo, Chen Hao, de la Iglesia, Janis, Roselli, Emiliano, Benzaïd, Ismahène, Wang, Xuefeng, Kim, Youngchul, Lynch, Conor C., Abate-Daga, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156127/ https://www.ncbi.nlm.nih.gov/pubmed/37134157 http://dx.doi.org/10.1126/sciadv.adf0108

Ejemplares similares

Use of phage display biopanning as a tool to design CAR-T cells against glioma stem cells
por: Potez, Marine, et al.
Publicado: (2023)

CAR models: next-generation CAR modifications for enhanced T-cell function
por: Abate-Daga, Daniel, et al.
Publicado: (2016)

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome
por: Rodriguez-Marquez, Paula, et al.
Publicado: (2022)

Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion
por: Rejeski, Kai, et al.
Publicado: (2023)

Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans
por: Chen, Xu, et al.
Publicado: (2022)

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies
por: Abate-Daga, Daniel, et al.
Publicado: (2014)

EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors
por: Li, Dan, et al.
Publicado: (2023)

Development of anti-somatostatin receptors CAR T cells for treatment of neuroendocrine tumors
por: Mandriani, Barbara, et al.
Publicado: (2022)

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
por: Baker, Alexander T., et al.
Publicado: (2021)

Surficial nano-deposition locoregionally yielding bactericidal super CAR-macrophages expedites periprosthetic osseointegration
por: Li, Ziyang, et al.
Publicado: (2023)

Constitutive Turbodomains enhance expansion and antitumor activity of allogeneic BCMA CAR T cells in preclinical models
por: Lin, Regina J., et al.
Publicado: (2023)

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors
por: Grosskopf, Abigail K., et al.
Publicado: (2022)

TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells
por: Collins, Sierra M., et al.
Publicado: (2023)

Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering
por: Li, Li, et al.
Publicado: (2023)

Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases
por: Pan, Xin, et al.
Publicado: (2010)

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
por: Zhu, Bo-feng, et al.
Publicado: (2010)

Sporadic Creutzfeldt–Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling
por: Gawinecka, Joanna, et al.
Publicado: (2012)

Surface modifications of influenza proteins upon virus inactivation by β-propiolactone*
por: She, Yi-Min, et al.
Publicado: (2013)

Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissues
por: Steiner, Carine, et al.
Publicado: (2014)

MALDI Mass Spectrometry Imaging: A Novel Tool for the Identification and Classification of Amyloidosis
por: Winter, Martin, et al.
Publicado: (2017)

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care
por: Chung, Ha Uk, et al.
Publicado: (2019)

Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
por: von Stechow, Louise, et al.
Publicado: (2016)

Proteomic characterization of microdissected breast tissue environment provides a protein‐level overview of malignant transformation
por: Braakman, René B. H., et al.
Publicado: (2017)

Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL
por: Bai, Zhiliang, et al.
Publicado: (2022)

Infectious Diseases, Trade, and Economic Growth: a Panel Analysis of Developed and Developing Countries
por: Ismahene, Yahyaoui
Publicado: (2021)

BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
por: Huang, Shi‐Wei, et al.
Publicado: (2023)

Bispecific PSMA antibodies and CAR-T in metastatic castration-resistant prostate cancer
por: Zarrabi, Kevin K., et al.
Publicado: (2023)

Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat
por: Hooy, Richard M., et al.
Publicado: (2022)

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
por: Legut, Mateusz, et al.
Publicado: (2015)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023)

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
por: Ren, Xuefeng, et al.
Publicado: (2023)

Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
por: Akitsu, Aoi, et al.
Publicado: (2018)

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy
por: Ferry, Gabrielle M., et al.
Publicado: (2022)

Lipid-induced DRAM recruits STOM to lysosomes and induces LMP to promote exosome release from hepatocytes in NAFLD
por: Zhang, Jie, et al.
Publicado: (2021)

The Aging of γδ T Cells
por: Xu, Weili, et al.
Publicado: (2020)

Medicalization: Current Concept and Future Directions in a Bionic Society
por: Maturo, Antonio
Publicado: (2012)

Democracy, Human Rights and Women's Health
por: Safaei, Jalil
Publicado: (2012)

Of Money and Trust in Medical Care Redux
por: Lexchin, Joel
Publicado: (2012)

Inmunohistochemical detection of pandemic SARS-CoV-2 antigens in lung tissue
por: Rivera, Jorge, et al.
Publicado: (2022)

Histopathology of COVID-19: An illustration of the findings from fatal cases
por: Rivera, Jorge, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_380pspl96fbnfrojildh9gn851