Cargando…

Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study

BACKGROUND: This single-centre study investigated factors influencing death in coronavirus disease 2019 (COVID-19) patients treated in an intensive care unit (ICU). METHODS: Data of 113 consecutive patients with a severe form of COVID-19 infection, who completed their ICU stay in a large COVID-19-de...

Descripción completa

Detalles Bibliográficos
Autores principales: Kokoszka-Bargieł, Izabela, Cyprys, Paweł, Madeja, Patryk, Rutkowska, Katarzyna, Wajda-Pokrontka, Marta, Madowicz, Jarosław, Knapik, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156494/
https://www.ncbi.nlm.nih.gov/pubmed/35702812
http://dx.doi.org/10.5114/ait.2022.116231
_version_ 1785036552076787712
author Kokoszka-Bargieł, Izabela
Cyprys, Paweł
Madeja, Patryk
Rutkowska, Katarzyna
Wajda-Pokrontka, Marta
Madowicz, Jarosław
Knapik, Piotr
author_facet Kokoszka-Bargieł, Izabela
Cyprys, Paweł
Madeja, Patryk
Rutkowska, Katarzyna
Wajda-Pokrontka, Marta
Madowicz, Jarosław
Knapik, Piotr
author_sort Kokoszka-Bargieł, Izabela
collection PubMed
description BACKGROUND: This single-centre study investigated factors influencing death in coronavirus disease 2019 (COVID-19) patients treated in an intensive care unit (ICU). METHODS: Data of 113 consecutive patients with a severe form of COVID-19 infection, who completed their ICU stay in a large COVID-19-dedicated hospital in the Silesian Region of Poland during one year of the pandemic (between 10 March, 2020 and 10 March, 2021), were reviewed. Comprehensive comparison of all available ICU pre-admission, admission and treatment variables was performed. Variables that independently influenced ICU death were identified. RESULTS: ICU mortality in the whole group was 64.6%. Mean age was higher in non-survivors (64.6 ± 9.5 vs. 60.0 ± 12.8 years, P = 0.036), but the distribution of sex and body mass index was similar in both groups. Non-survivors had a marginally higher mean Charlson Comorbidity Index (5.9 ± 3.6 vs. 4.5 ± 4.1 points, P = 0.063), and significantly higher mean Clinical Frailty Score (4.8 ± 1.5 vs. 3.9 ± 1.4 points, P = 0.004), admission APACHE II score (22.9 ± 7.9 vs. 19.1 ± 7.8 points, P = 0.017) and SAPS II score (62.1 ± 18.1 vs. 54.0 ± 16.7 points, P = 0.023). Factors that independently influenced ICU death were limited to: admission total protein < 50 g L(–1) (OR = 11.5, P = 0.002), procalcitonin level > 2.0 ng mL(–1) (OR = 11.3, P = 0.026) and lactate level > 2.0 mmol L(–1) (OR = 4.2, P = 0.003) as well as Clinical Frailty Score ≥ 5 points (OR = 3.1, P = 0.021). CONCLUSIONS: The presence of low total protein, frailty and increased procalcitonin and lactate levels at ICU admission are associated with ICU death in patients with severe COVID-19 infection.
format Online
Article
Text
id pubmed-10156494
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-101564942023-05-17 Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study Kokoszka-Bargieł, Izabela Cyprys, Paweł Madeja, Patryk Rutkowska, Katarzyna Wajda-Pokrontka, Marta Madowicz, Jarosław Knapik, Piotr Anaesthesiol Intensive Ther Original and Clinical Articles BACKGROUND: This single-centre study investigated factors influencing death in coronavirus disease 2019 (COVID-19) patients treated in an intensive care unit (ICU). METHODS: Data of 113 consecutive patients with a severe form of COVID-19 infection, who completed their ICU stay in a large COVID-19-dedicated hospital in the Silesian Region of Poland during one year of the pandemic (between 10 March, 2020 and 10 March, 2021), were reviewed. Comprehensive comparison of all available ICU pre-admission, admission and treatment variables was performed. Variables that independently influenced ICU death were identified. RESULTS: ICU mortality in the whole group was 64.6%. Mean age was higher in non-survivors (64.6 ± 9.5 vs. 60.0 ± 12.8 years, P = 0.036), but the distribution of sex and body mass index was similar in both groups. Non-survivors had a marginally higher mean Charlson Comorbidity Index (5.9 ± 3.6 vs. 4.5 ± 4.1 points, P = 0.063), and significantly higher mean Clinical Frailty Score (4.8 ± 1.5 vs. 3.9 ± 1.4 points, P = 0.004), admission APACHE II score (22.9 ± 7.9 vs. 19.1 ± 7.8 points, P = 0.017) and SAPS II score (62.1 ± 18.1 vs. 54.0 ± 16.7 points, P = 0.023). Factors that independently influenced ICU death were limited to: admission total protein < 50 g L(–1) (OR = 11.5, P = 0.002), procalcitonin level > 2.0 ng mL(–1) (OR = 11.3, P = 0.026) and lactate level > 2.0 mmol L(–1) (OR = 4.2, P = 0.003) as well as Clinical Frailty Score ≥ 5 points (OR = 3.1, P = 0.021). CONCLUSIONS: The presence of low total protein, frailty and increased procalcitonin and lactate levels at ICU admission are associated with ICU death in patients with severe COVID-19 infection. Termedia Publishing House 2022-06-13 /pmc/articles/PMC10156494/ /pubmed/35702812 http://dx.doi.org/10.5114/ait.2022.116231 Text en Copyright © Polish Society of Anaesthesiology and Intensive Therapy https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original and Clinical Articles
Kokoszka-Bargieł, Izabela
Cyprys, Paweł
Madeja, Patryk
Rutkowska, Katarzyna
Wajda-Pokrontka, Marta
Madowicz, Jarosław
Knapik, Piotr
Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study
title Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study
title_full Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study
title_fullStr Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study
title_full_unstemmed Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study
title_short Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study
title_sort factors influencing death in covid-19 patients treated in the icu: a single-centre, cross-sectional study
topic Original and Clinical Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156494/
https://www.ncbi.nlm.nih.gov/pubmed/35702812
http://dx.doi.org/10.5114/ait.2022.116231
work_keys_str_mv AT kokoszkabargiełizabela factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy
AT cypryspaweł factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy
AT madejapatryk factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy
AT rutkowskakatarzyna factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy
AT wajdapokrontkamarta factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy
AT madowiczjarosław factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy
AT knapikpiotr factorsinfluencingdeathincovid19patientstreatedintheicuasinglecentrecrosssectionalstudy