Wisdom of the Crowd: insights gained from comparing predicted and observed effects of blood pressure lowering strategies

In a first of its kind assessment in cardiovascular research, we assessed whether pooled cardiovascular expertise could accurately predict efficacy and tolerability for both a novel and an established treatment option. A survey was administered prior to the publication of the QUARTET (A Quadruple Ul...

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Detalles Bibliográficos
Autores principales: Gnanenthiran, Sonali R., Jha, Vivekanand, Salam, Abdul, Atkins, Emily, Chow, Clara K., Nelson, Mark R., Rakotz, Mike, Schlaich, Markus P., Schutte, Aletta E., Usherwood, Tim, Rodgers, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156589/
https://www.ncbi.nlm.nih.gov/pubmed/37041253
http://dx.doi.org/10.1038/s41371-023-00816-y
Descripción
Sumario:In a first of its kind assessment in cardiovascular research, we assessed whether pooled cardiovascular expertise could accurately predict efficacy and tolerability for both a novel and an established treatment option. A survey was administered prior to the publication of the QUARTET (A Quadruple UltrA-low-dose tReatment for hypErTension) trial. QUARTET was a multicentre, double-blind, parallel-group, trial that randomised participants to initial treatment with either monotherapy or an ultra-low dose quadruple single pill combination for 12 weeks. Survey participants were asked to predict blood pressure (BP) at 12 weeks and 52 weeks for both groups.

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