Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

BACKGROUND: Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cross-resistant to clofazimine. To decipher bedaquili...

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Detalles Bibliográficos
Autores principales: Sonnenkalb, Lindsay, Carter, Joshua James, Spitaleri, Andrea, Iqbal, Zamin, Hunt, Martin, Malone, Kerri Marie, Utpatel, Christian, Cirillo, Daniela Maria, Rodrigues, Camilla, Nilgiriwala, Kayzad Soli, Fowler, Philip William, Merker, Matthias, Niemann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156607/
https://www.ncbi.nlm.nih.gov/pubmed/37003285
http://dx.doi.org/10.1016/S2666-5247(23)00002-2

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