Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair

Due to its complex and multifaceted nature, developing effective treatments for epilepsy is still a major challenge. To deal with this complexity we introduce the concept of degeneracy to the field of epilepsy research: the ability of disparate elements to cause an analogous function or malfunction....

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Autores principales: Stöber, Tristan Manfred, Batulin, Danylo, Triesch, Jochen, Narayanan, Rishikesh, Jedlicka, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156698/
https://www.ncbi.nlm.nih.gov/pubmed/37137938
http://dx.doi.org/10.1038/s42003-023-04823-0
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author Stöber, Tristan Manfred
Batulin, Danylo
Triesch, Jochen
Narayanan, Rishikesh
Jedlicka, Peter
author_facet Stöber, Tristan Manfred
Batulin, Danylo
Triesch, Jochen
Narayanan, Rishikesh
Jedlicka, Peter
author_sort Stöber, Tristan Manfred
collection PubMed
description Due to its complex and multifaceted nature, developing effective treatments for epilepsy is still a major challenge. To deal with this complexity we introduce the concept of degeneracy to the field of epilepsy research: the ability of disparate elements to cause an analogous function or malfunction. Here, we review examples of epilepsy-related degeneracy at multiple levels of brain organisation, ranging from the cellular to the network and systems level. Based on these insights, we outline new multiscale and population modelling approaches to disentangle the complex web of interactions underlying epilepsy and to design personalised multitarget therapies.
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spelling pubmed-101566982023-05-05 Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair Stöber, Tristan Manfred Batulin, Danylo Triesch, Jochen Narayanan, Rishikesh Jedlicka, Peter Commun Biol Perspective Due to its complex and multifaceted nature, developing effective treatments for epilepsy is still a major challenge. To deal with this complexity we introduce the concept of degeneracy to the field of epilepsy research: the ability of disparate elements to cause an analogous function or malfunction. Here, we review examples of epilepsy-related degeneracy at multiple levels of brain organisation, ranging from the cellular to the network and systems level. Based on these insights, we outline new multiscale and population modelling approaches to disentangle the complex web of interactions underlying epilepsy and to design personalised multitarget therapies. Nature Publishing Group UK 2023-05-03 /pmc/articles/PMC10156698/ /pubmed/37137938 http://dx.doi.org/10.1038/s42003-023-04823-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Stöber, Tristan Manfred
Batulin, Danylo
Triesch, Jochen
Narayanan, Rishikesh
Jedlicka, Peter
Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
title Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
title_full Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
title_fullStr Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
title_full_unstemmed Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
title_short Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
title_sort degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156698/
https://www.ncbi.nlm.nih.gov/pubmed/37137938
http://dx.doi.org/10.1038/s42003-023-04823-0
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