N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry

Oxidized cysteine residues are highly reactive and can form functional covalent conjugates, of which the allosteric redox switch formed by the lysine-cysteine NOS bridge is an example. Here, we report a noncanonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycino...

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Detalles Bibliográficos
Autores principales: Wang, Yung-Lin, Chang, Chin-Yuan, Hsu, Ning-Shian, Lo, I-Wen, Lin, Kuan-Hung, Chen, Chun-Liang, Chang, Chi-Fon, Wang, Zhe-Chong, Ogasawara, Yasushi, Dairi, Tohru, Maruyama, Chitose, Hamano, Yoshimitsu, Li, Tsung-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156733/
https://www.ncbi.nlm.nih.gov/pubmed/37137912
http://dx.doi.org/10.1038/s41467-023-38218-w

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