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The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent

INTRODUCTION: Fluoropyrimidines, principally 5-fluorouracil (5-FU), remain a key component of chemotherapy regimens for multiple cancer types, in particular colorectal and other gastrointestinal malignancies. To overcome key limitations and pharmacologic challenges that hinder the clinical utility o...

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Detalles Bibliográficos
Autores principales:	Bré, Jennifer, Dickson, Alison L., Read, Oliver J., Zhang, Ying, McKissock, Fiona G., Mullen, Peter, Tang, Peijun, Zickuhr, Greice M., Czekster, Clarissa M., Harrison, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156769/ https://www.ncbi.nlm.nih.gov/pubmed/37000221 http://dx.doi.org/10.1007/s00280-023-04528-5

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