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Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species
Coagulase-negative Staphylococcus (CoNS) are opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS remains obscure because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. Here, we sequenced the genome...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156822/ https://www.ncbi.nlm.nih.gov/pubmed/37137974 http://dx.doi.org/10.1038/s42003-023-04877-0 |
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author | Ikhimiukor, Odion O. Souza, Stephanie S. R. Marcovici, Michael M. Nye, Griffin J. Gibson, Robert Andam, Cheryl P. |
author_facet | Ikhimiukor, Odion O. Souza, Stephanie S. R. Marcovici, Michael M. Nye, Griffin J. Gibson, Robert Andam, Cheryl P. |
author_sort | Ikhimiukor, Odion O. |
collection | PubMed |
description | Coagulase-negative Staphylococcus (CoNS) are opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS remains obscure because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. Here, we sequenced the genomes of 191 CoNS isolates representing 15 species sampled from diseased animals diagnosed in a veterinary diagnostic laboratory. We found that CoNS are important reservoirs of diverse phages, plasmids and mobilizable genes encoding antimicrobial resistance, heavy metal resistance, and virulence. Frequent exchange of DNA between certain donor-recipient partners suggests that specific lineages act as hubs of gene sharing. We also detected frequent recombination between CoNS regardless of their animal host species, indicating that ecological barriers to horizontal gene transfer can be surmounted in co-circulating lineages. Our findings reveal frequent but structured patterns of transfer that exist within and between CoNS species, which are driven by their overlapping ecology and geographical proximity. |
format | Online Article Text |
id | pubmed-10156822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101568222023-05-05 Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species Ikhimiukor, Odion O. Souza, Stephanie S. R. Marcovici, Michael M. Nye, Griffin J. Gibson, Robert Andam, Cheryl P. Commun Biol Article Coagulase-negative Staphylococcus (CoNS) are opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS remains obscure because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. Here, we sequenced the genomes of 191 CoNS isolates representing 15 species sampled from diseased animals diagnosed in a veterinary diagnostic laboratory. We found that CoNS are important reservoirs of diverse phages, plasmids and mobilizable genes encoding antimicrobial resistance, heavy metal resistance, and virulence. Frequent exchange of DNA between certain donor-recipient partners suggests that specific lineages act as hubs of gene sharing. We also detected frequent recombination between CoNS regardless of their animal host species, indicating that ecological barriers to horizontal gene transfer can be surmounted in co-circulating lineages. Our findings reveal frequent but structured patterns of transfer that exist within and between CoNS species, which are driven by their overlapping ecology and geographical proximity. Nature Publishing Group UK 2023-05-03 /pmc/articles/PMC10156822/ /pubmed/37137974 http://dx.doi.org/10.1038/s42003-023-04877-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ikhimiukor, Odion O. Souza, Stephanie S. R. Marcovici, Michael M. Nye, Griffin J. Gibson, Robert Andam, Cheryl P. Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species |
title | Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species |
title_full | Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species |
title_fullStr | Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species |
title_full_unstemmed | Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species |
title_short | Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species |
title_sort | leaky barriers to gene sharing between locally co-existing coagulase-negative staphylococcus species |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156822/ https://www.ncbi.nlm.nih.gov/pubmed/37137974 http://dx.doi.org/10.1038/s42003-023-04877-0 |
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