Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome

OBJECTIVE: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). METHODS: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thought...

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Detalles Bibliográficos
Autores principales: Kim, Jae-Min, Kang, Hee-Ju, Kim, Ju-Wan, Choi, Wonsuk, Kim, Sung-Wan, Kim, Jung-Chul, Chun, Byung Jo, Ahn, Youngkeun, Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157011/
https://www.ncbi.nlm.nih.gov/pubmed/37119231
http://dx.doi.org/10.9758/cpn.2023.21.2.386
Descripción
Sumario:OBJECTIVE: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). METHODS: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates. RESULTS: Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group. CONCLUSION: By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.

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