Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome

OBJECTIVE: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). METHODS: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thought...

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Autores principales: Kim, Jae-Min, Kang, Hee-Ju, Kim, Ju-Wan, Choi, Wonsuk, Kim, Sung-Wan, Kim, Jung-Chul, Chun, Byung Jo, Ahn, Youngkeun, Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157011/
https://www.ncbi.nlm.nih.gov/pubmed/37119231
http://dx.doi.org/10.9758/cpn.2023.21.2.386
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author Kim, Jae-Min
Kang, Hee-Ju
Kim, Ju-Wan
Choi, Wonsuk
Kim, Sung-Wan
Kim, Jung-Chul
Chun, Byung Jo
Ahn, Youngkeun
Jeong, Myung Ho
author_facet Kim, Jae-Min
Kang, Hee-Ju
Kim, Ju-Wan
Choi, Wonsuk
Kim, Sung-Wan
Kim, Jung-Chul
Chun, Byung Jo
Ahn, Youngkeun
Jeong, Myung Ho
author_sort Kim, Jae-Min
collection PubMed
description OBJECTIVE: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). METHODS: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates. RESULTS: Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group. CONCLUSION: By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
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spelling pubmed-101570112023-05-30 Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome Kim, Jae-Min Kang, Hee-Ju Kim, Ju-Wan Choi, Wonsuk Kim, Sung-Wan Kim, Jung-Chul Chun, Byung Jo Ahn, Youngkeun Jeong, Myung Ho Clin Psychopharmacol Neurosci Brief Report OBJECTIVE: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). METHODS: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates. RESULTS: Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group. CONCLUSION: By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved. Korean College of Neuropsychopharmacology 2023-05-30 2023-05-30 /pmc/articles/PMC10157011/ /pubmed/37119231 http://dx.doi.org/10.9758/cpn.2023.21.2.386 Text en Copyright© 2023, Korean College of Neuropsychopharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Kim, Jae-Min
Kang, Hee-Ju
Kim, Ju-Wan
Choi, Wonsuk
Kim, Sung-Wan
Kim, Jung-Chul
Chun, Byung Jo
Ahn, Youngkeun
Jeong, Myung Ho
Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
title Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
title_full Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
title_fullStr Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
title_full_unstemmed Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
title_short Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
title_sort possible link between serotonin and interleukin 18 on suicidality in patients with acute coronary syndrome
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157011/
https://www.ncbi.nlm.nih.gov/pubmed/37119231
http://dx.doi.org/10.9758/cpn.2023.21.2.386
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