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IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium

Mucosal delivery of IL-27 has been shown to have a therapeutic benefit in murine models of inflammatory bowel disease (IBD). The IL-27 effect was associated with phosphorylated STAT1 (pSTAT1), a product of IL27 receptor signaling, in bowel tissue. To determine whether IL-27 acted directly on colonic...

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Detalles Bibliográficos
Autores principales:	Andrews, Caroline, McLean, Mairi H., Hixon, Julie A., Pontejo, Sergio M., Starr, Tregei, Malo, Courtney, Cam, Margaret, Ridnour, Lisa, Hickman, Heather, Steele-Mortimer, Olivia, Wink, David A., Young, Howard A., McVicar, Daniel W., Li, Wenqing, Durum, Scott K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157156/ https://www.ncbi.nlm.nih.gov/pubmed/37153622 http://dx.doi.org/10.3389/fimmu.2023.1021824

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