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N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis

As our previous study revealed that N-benzyl-N-methyldecan-1-amine (BMDA), a new molecule originated from Allium sativum, exhibits anti-neoplastic activities, we herein explored other functions of the compound and its derivative [decyl-(4-methoxy-benzyl)-methyl-amine; DMMA] including anti-inflammato...

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Autores principales: Kim, Ji Eun, Kang, Changyu, Budluang, Phatcharaporn, Yawut, Natpaphan, Cho, Il-Rae, Choi, Yun Ju, Kim, Jaejeong, Ju, Sanghyun, Lee, Beomgu, Sohn, Dong Hyun, Yim, Hyung-Soon, Lee, Kyeong Won, Han, Jinsol, Jung, Youngmi, Kang, Ho Young, Park, Jin Kyoon, Jung, Yunjin, Hwang, Dae Youn, Chung, Young-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157284/
https://www.ncbi.nlm.nih.gov/pubmed/37153778
http://dx.doi.org/10.3389/fphar.2023.1095955
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author Kim, Ji Eun
Kang, Changyu
Budluang, Phatcharaporn
Yawut, Natpaphan
Cho, Il-Rae
Choi, Yun Ju
Kim, Jaejeong
Ju, Sanghyun
Lee, Beomgu
Sohn, Dong Hyun
Yim, Hyung-Soon
Lee, Kyeong Won
Han, Jinsol
Jung, Youngmi
Kang, Ho Young
Park, Jin Kyoon
Jung, Yunjin
Hwang, Dae Youn
Chung, Young-Hwa
author_facet Kim, Ji Eun
Kang, Changyu
Budluang, Phatcharaporn
Yawut, Natpaphan
Cho, Il-Rae
Choi, Yun Ju
Kim, Jaejeong
Ju, Sanghyun
Lee, Beomgu
Sohn, Dong Hyun
Yim, Hyung-Soon
Lee, Kyeong Won
Han, Jinsol
Jung, Youngmi
Kang, Ho Young
Park, Jin Kyoon
Jung, Yunjin
Hwang, Dae Youn
Chung, Young-Hwa
author_sort Kim, Ji Eun
collection PubMed
description As our previous study revealed that N-benzyl-N-methyldecan-1-amine (BMDA), a new molecule originated from Allium sativum, exhibits anti-neoplastic activities, we herein explored other functions of the compound and its derivative [decyl-(4-methoxy-benzyl)-methyl-amine; DMMA] including anti-inflammatory and anti-oxidative activities. Pretreatment of THP-1 cells with BMDA or DMMA inhibited tumor necrosis factor (TNF)-α and interleukin (IL)-1β production, and blocked c-jun terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), MAPKAP kinase (MK)2 and NF-κΒ inflammatory signaling during LPS stimulation. Rectal treatment with BMDA or DMMA reduced the severity of colitis in 2,4-dinitrobenzenesulfonic acid (DNBS)-treated rat. Consistently, administration of the compounds decreased myeloperoxidase (MPO) activity (representing neutrophil infiltration in colonic mucosa), production of inflammatory mediators such as cytokine-induced neutrophil chemoattractant (CINC)-3 and TNF-α, and activation of JNK and p38 MAPK in the colon tissues. In addition, oral administration of these compounds ameliorated collagen-induced rheumatoid arthritis (RA) in mice. The treatment diminished the levels of inflammatory cytokine transcripts, and protected connective tissues through the expression of anti-oxidation proteins such as nuclear factor erythroid-related factor (Nrf)2 and heme oxygenase (HO)1. Additionally, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels did not differ between the BMDA- or DMMA-treated and control animals, indicating that the compounds do not possess liver toxicity. Taken together, these findings propose that BMDA and DMMA could be used as new drugs for curing inflammatory bowel disease (IBD) and RA.
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spelling pubmed-101572842023-05-05 N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis Kim, Ji Eun Kang, Changyu Budluang, Phatcharaporn Yawut, Natpaphan Cho, Il-Rae Choi, Yun Ju Kim, Jaejeong Ju, Sanghyun Lee, Beomgu Sohn, Dong Hyun Yim, Hyung-Soon Lee, Kyeong Won Han, Jinsol Jung, Youngmi Kang, Ho Young Park, Jin Kyoon Jung, Yunjin Hwang, Dae Youn Chung, Young-Hwa Front Pharmacol Pharmacology As our previous study revealed that N-benzyl-N-methyldecan-1-amine (BMDA), a new molecule originated from Allium sativum, exhibits anti-neoplastic activities, we herein explored other functions of the compound and its derivative [decyl-(4-methoxy-benzyl)-methyl-amine; DMMA] including anti-inflammatory and anti-oxidative activities. Pretreatment of THP-1 cells with BMDA or DMMA inhibited tumor necrosis factor (TNF)-α and interleukin (IL)-1β production, and blocked c-jun terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), MAPKAP kinase (MK)2 and NF-κΒ inflammatory signaling during LPS stimulation. Rectal treatment with BMDA or DMMA reduced the severity of colitis in 2,4-dinitrobenzenesulfonic acid (DNBS)-treated rat. Consistently, administration of the compounds decreased myeloperoxidase (MPO) activity (representing neutrophil infiltration in colonic mucosa), production of inflammatory mediators such as cytokine-induced neutrophil chemoattractant (CINC)-3 and TNF-α, and activation of JNK and p38 MAPK in the colon tissues. In addition, oral administration of these compounds ameliorated collagen-induced rheumatoid arthritis (RA) in mice. The treatment diminished the levels of inflammatory cytokine transcripts, and protected connective tissues through the expression of anti-oxidation proteins such as nuclear factor erythroid-related factor (Nrf)2 and heme oxygenase (HO)1. Additionally, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels did not differ between the BMDA- or DMMA-treated and control animals, indicating that the compounds do not possess liver toxicity. Taken together, these findings propose that BMDA and DMMA could be used as new drugs for curing inflammatory bowel disease (IBD) and RA. Frontiers Media S.A. 2023-04-20 /pmc/articles/PMC10157284/ /pubmed/37153778 http://dx.doi.org/10.3389/fphar.2023.1095955 Text en Copyright © 2023 Kim, Kang, Budluang, Yawut, Cho, Choi, Kim, Ju, Lee, Sohn, Yim, Lee, Han, Jung, Kang, Park, Jung, Hwang and Chung. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kim, Ji Eun
Kang, Changyu
Budluang, Phatcharaporn
Yawut, Natpaphan
Cho, Il-Rae
Choi, Yun Ju
Kim, Jaejeong
Ju, Sanghyun
Lee, Beomgu
Sohn, Dong Hyun
Yim, Hyung-Soon
Lee, Kyeong Won
Han, Jinsol
Jung, Youngmi
Kang, Ho Young
Park, Jin Kyoon
Jung, Yunjin
Hwang, Dae Youn
Chung, Young-Hwa
N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
title N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
title_full N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
title_fullStr N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
title_full_unstemmed N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
title_short N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
title_sort n-benzyl-n-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157284/
https://www.ncbi.nlm.nih.gov/pubmed/37153778
http://dx.doi.org/10.3389/fphar.2023.1095955
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