Cargando…

Progesterone and its metabolite allopregnanolone promote invasion of human glioblastoma cells through metalloproteinase‑9 and cSrc kinase

Glioblastomas are the most aggressive and common primary brain tumors in adults. Glioblastoma cells have a great capacity to migrate and invade the brain parenchyma, often reaching the contralateral hemisphere. Progesterone (P4) and its metabolite, allopregnanolone (3α-THP), promote the migration an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bello-Alvarez, Claudia, Zamora-Sánchez, Carmen J., Peña-Gutiérrez, Karla M., Camacho-Arroyo, Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157356/ https://www.ncbi.nlm.nih.gov/pubmed/37153033 http://dx.doi.org/10.3892/ol.2023.13809

Ejemplares similares

Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer
por: Bello-Alvarez, Claudia, et al.
Publicado: (2022)

Intracellular Progesterone Receptor and cSrc Protein Working Together to Regulate the Activity of Proteins Involved in Migration and Invasion of Human Glioblastoma Cells
por: Bello-Alvarez, Claudia, et al.
Publicado: (2021)

Allopregnanolone Promotes Migration and Invasion of Human Glioblastoma Cells through the Protein Tyrosine Kinase c-Src Activation
por: Zamora-Sánchez, Carmen J., et al.
Publicado: (2022)

Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells
por: Zamora-Sánchez, Carmen J., et al.
Publicado: (2018)

Allopregnanolone: Metabolism, Mechanisms of Action, and Its Role in Cancer
por: Zamora-Sánchez, Carmen J., et al.
Publicado: (2022)

Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt
por: Mani, Vadivel, et al.
Publicado: (2021)

Trajectories of Allopregnanolone and Allopregnanolone to Progesterone Ratio across the Six Subphases of Menstrual Cycle
por: Hamidovic, Ajna, et al.
Publicado: (2023)

Activation of the Non-receptor Tyrosine Kinase cSrc in Macrophage-rich Atherosclerotic Plaques of Human Carotid Arteries
por: Toi, Sono, et al.
Publicado: (2007)

Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis
por: Novikov, F. N., et al.
Publicado: (2021)

Expression and estrogen regulation of G protein-coupled estrogen receptor in human glioblastoma cells
por: Peña-Gutiérrez, Karla Mariana, et al.
Publicado: (2022)

Author Correction: Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis
por: Novikov, F. N., et al.
Publicado: (2022)

Proliferative and Invasive Effects of Progesterone-Induced Blocking Factor in Human Glioblastoma Cells
por: Gutiérrez-Rodríguez, Araceli, et al.
Publicado: (2017)

Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland
por: Cunnick, Jess M, et al.
Publicado: (2014)

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling
por: Liu, Yong-Yu, et al.
Publicado: (2010)

Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones
por: Bello-Alvarez, Claudia, et al.
Publicado: (2021)

Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
por: Novick, Andrew M., et al.
Publicado: (2022)

A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits
por: Cao, Ting, et al.
Publicado: (2021)

GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway
por: Lluis, Josep M., et al.
Publicado: (2009)

Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells
por: Thomas, Peter, et al.
Publicado: (2020)

Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study
por: Rustichelli, Cecilia, et al.
Publicado: (2020)

Progesterone and Allopregnanolone Rapidly Attenuate Estrogen-Associated Mechanical Allodynia in Rats with Persistent Temporomandibular Joint Inflammation
por: Hornung, Rebecca S., et al.
Publicado: (2020)

SRC Kinase in Glioblastoma: News from an Old Acquaintance
por: Cirotti, Claudia, et al.
Publicado: (2020)

Expression analysis of progesterone-regulated miRNAs in cells derived from human glioblastoma
por: Velázquez-Vázquez, Diana Elisa, et al.
Publicado: (2021)

Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis
por: González-Orozco, Juan Carlos, et al.
Publicado: (2020)

LPA(1) Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells
por: Valdés-Rives, Silvia Anahi, et al.
Publicado: (2021)

Allopregnanolone in Postpartum Depression
por: Pinna, Graziano, et al.
Publicado: (2022)

Progesterone Actions During Central Nervous System Development
por: González-Orozco, Juan Carlos, et al.
Publicado: (2019)

The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance
por: Torrisi, Filippo, et al.
Publicado: (2020)

Differential Regulation of CsrC and CsrB by CRP-cAMP in Salmonella enterica
por: El Mouali, Youssef, et al.
Publicado: (2020)

Allopregnanolone and neurogenesis in the nigrostriatal tract
por: Wang, Jun Ming
Publicado: (2014)

Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation
por: Roy, Kartik R., et al.
Publicado: (2020)

NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
por: Cirotti, Claudia, et al.
Publicado: (2023)

Allopregnanolone and Its Precursor Progesterone Do Not Reduce Injury after Experimental Stroke in Hypertensive Rats – Role of Postoperative Temperature Regulation?
por: Spratt, Neil J., et al.
Publicado: (2014)

EZH2 Mediates Proliferation, Migration, and Invasion Promoted by Estradiol in Human Glioblastoma Cells
por: Del Moral-Morales, Aylin, et al.
Publicado: (2022)

High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression
por: Timmermans-Sprang, Elpetra P. M., et al.
Publicado: (2015)

Corrigendum: Differential Regulation of CsrC and CsrB by CRP-cAMP in Salmonella enterica
por: El Mouali, Youssef, et al.
Publicado: (2021)

Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease
por: Irwin, Ronald W., et al.
Publicado: (2012)

Biosynthesis and biological action of pineal allopregnanolone
por: Tsutsui, Kazuyoshi, et al.
Publicado: (2014)

Allopregnanolone: An overview on its synthesis and effects
por: Diviccaro, Silvia, et al.
Publicado: (2021)

Testosterone Promotes Glioblastoma Cell Proliferation, Migration, and Invasion Through Androgen Receptor Activation
por: Rodríguez-Lozano, Dulce Carolina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_knnnl9k1mqrg8hsphs2m8sb70j