Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death

High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer subtype. PARP inhibitors (PARPi) have become the mainstay of HGSC-targeted therapy, given that these tumors are driven by a high degree of genomic instability (GI) and homologous recombination (HR) defects. Nonetheless,...

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Detalles Bibliográficos
Autores principales: Avelar, Rita A., Armstrong, Amy J., Carvette, Gracie, Gupta, Riya, Puleo, Noah, Colina, Jose A., Joseph, Peronne, Sobeck, Alexander M., O'Connor, Caitlin M., Raines, Brynne, Gandhi, Agharnan, Dziubinski, Michele L., Ma, Daniel S., Resnick, Kimberly, Singh, Sareena, Zanotti, Kristine, Nagel, Christa, Waggoner, Steven, Thomas, Daffyd G., Skala, Stephanie L., Zhang, Junran, Narla, Goutham, DiFeo, Analisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157366/
https://www.ncbi.nlm.nih.gov/pubmed/36788429
http://dx.doi.org/10.1158/1535-7163.MCT-21-0880

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