The role of interleukin-15 in the development and treatment of hematological malignancies

Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been sho...

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Autores principales: Sindaco, Paola, Pandey, Hritisha, Isabelle, Colleen, Chakravarti, Nitin, Brammer, Jonathan Edward, Porcu, Pierluigi, Mishra, Anjali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157481/
https://www.ncbi.nlm.nih.gov/pubmed/37153603
http://dx.doi.org/10.3389/fimmu.2023.1141208
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author Sindaco, Paola
Pandey, Hritisha
Isabelle, Colleen
Chakravarti, Nitin
Brammer, Jonathan Edward
Porcu, Pierluigi
Mishra, Anjali
author_facet Sindaco, Paola
Pandey, Hritisha
Isabelle, Colleen
Chakravarti, Nitin
Brammer, Jonathan Edward
Porcu, Pierluigi
Mishra, Anjali
author_sort Sindaco, Paola
collection PubMed
description Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.
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spelling pubmed-101574812023-05-05 The role of interleukin-15 in the development and treatment of hematological malignancies Sindaco, Paola Pandey, Hritisha Isabelle, Colleen Chakravarti, Nitin Brammer, Jonathan Edward Porcu, Pierluigi Mishra, Anjali Front Immunol Immunology Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers. Frontiers Media S.A. 2023-04-20 /pmc/articles/PMC10157481/ /pubmed/37153603 http://dx.doi.org/10.3389/fimmu.2023.1141208 Text en Copyright © 2023 Sindaco, Pandey, Isabelle, Chakravarti, Brammer, Porcu and Mishra https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sindaco, Paola
Pandey, Hritisha
Isabelle, Colleen
Chakravarti, Nitin
Brammer, Jonathan Edward
Porcu, Pierluigi
Mishra, Anjali
The role of interleukin-15 in the development and treatment of hematological malignancies
title The role of interleukin-15 in the development and treatment of hematological malignancies
title_full The role of interleukin-15 in the development and treatment of hematological malignancies
title_fullStr The role of interleukin-15 in the development and treatment of hematological malignancies
title_full_unstemmed The role of interleukin-15 in the development and treatment of hematological malignancies
title_short The role of interleukin-15 in the development and treatment of hematological malignancies
title_sort role of interleukin-15 in the development and treatment of hematological malignancies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157481/
https://www.ncbi.nlm.nih.gov/pubmed/37153603
http://dx.doi.org/10.3389/fimmu.2023.1141208
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