Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway: Structural basis of the cefotetan-hRKIP interaction

Cefotetan is widely used to treat bacterial infections in the clinic owing to its broad spectrum of antibacterial activity. In the present study, we demonstrate that cefotetan can bind to the conserved ligand-binding pocket of human Raf1 kinase inhibitory protein (hRKIP), which acts as a negative re...

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Detalles Bibliográficos
Autores principales: Guo, Chenyun, Xu, Hao, Zhou, Yu, Wu, Zhihua, Jiang, Bin, Chen, Hanyu, Lin, Donghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157514/
https://www.ncbi.nlm.nih.gov/pubmed/36789691
http://dx.doi.org/10.3724/abbs.2022188

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