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Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study
Rare Disease patients manifested high concern regarding the possible increased risk of severe outcomes and worsening of disease-specific clinical manifestation due to the impact of COVID-19. Our aim was to assess the prevalence, outcomes, and impact of COVID-19 in patients with a rare disease such a...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157588/ https://www.ncbi.nlm.nih.gov/pubmed/37140873 http://dx.doi.org/10.1007/s11739-023-03287-8 |
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author | Suppressa, Patrizia Maiorano, Eugenia Gaetani, Eleonora Matti, Elina Lenato, Gennaro Mariano Serio, Ilaria Masala, Maristella Salvatora Passali, Giulio Cesare Aguglia, Maria Crocione, Claudia Lopalco, Pietro Luigi Caneschi, Francesca Musella, Valeria De Silvestri, Annalisa Gambini, Giulia Spinozzi, Giuseppe Sabbà, Carlo Pagella, Fabio |
author_facet | Suppressa, Patrizia Maiorano, Eugenia Gaetani, Eleonora Matti, Elina Lenato, Gennaro Mariano Serio, Ilaria Masala, Maristella Salvatora Passali, Giulio Cesare Aguglia, Maria Crocione, Claudia Lopalco, Pietro Luigi Caneschi, Francesca Musella, Valeria De Silvestri, Annalisa Gambini, Giulia Spinozzi, Giuseppe Sabbà, Carlo Pagella, Fabio |
author_sort | Suppressa, Patrizia |
collection | PubMed |
description | Rare Disease patients manifested high concern regarding the possible increased risk of severe outcomes and worsening of disease-specific clinical manifestation due to the impact of COVID-19. Our aim was to assess the prevalence, outcomes, and impact of COVID-19 in patients with a rare disease such as Hereditary Hemorrhagic Telangiectasia (HHT) in Italian population. A nationwide, multicentric, cross-sectional observational study was conducted on patients with HHT from five Italian HHT centers by online survey. The association between COVID-19-related signs and symptoms and nosebleeds worsening, the impact of personal protective equipment on nosebleeds pattern, and the relationship between the presence of visceral AVMs and severe outcomes were analyzed. Out of 605 total survey responses and eligible for analysis, 107 cases of COVID-19 were reported. A mild-course COVID-19 disease, not requiring hospitalization, was observed in 90.7% of patients, while the remaining eight cases needed hospitalization, two of them requiring intensive-care access. No fatal outcome was recorded and 79.3% of patients reported a complete recovery. No difference in infection risk and outcome between HHT patients and general population was evidenced. No significative interference of COVID-19 on HHT-related bleeding was found. The majority of patients received COVID-19 vaccination, with relevant impact on symptoms and need for hospitalization in case of infection. COVID-19 in HHT patients had an infection profile similar to the general population. COVID-19 course and outcome were independent from any specific HHT-related clinical features. Moreover, COVID-19 and anti-SARS-CoV-2 measures did not seem to affect significantly HHT-related bleeding profile. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11739-023-03287-8. |
format | Online Article Text |
id | pubmed-10157588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-101575882023-05-09 Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study Suppressa, Patrizia Maiorano, Eugenia Gaetani, Eleonora Matti, Elina Lenato, Gennaro Mariano Serio, Ilaria Masala, Maristella Salvatora Passali, Giulio Cesare Aguglia, Maria Crocione, Claudia Lopalco, Pietro Luigi Caneschi, Francesca Musella, Valeria De Silvestri, Annalisa Gambini, Giulia Spinozzi, Giuseppe Sabbà, Carlo Pagella, Fabio Intern Emerg Med Im - Original Rare Disease patients manifested high concern regarding the possible increased risk of severe outcomes and worsening of disease-specific clinical manifestation due to the impact of COVID-19. Our aim was to assess the prevalence, outcomes, and impact of COVID-19 in patients with a rare disease such as Hereditary Hemorrhagic Telangiectasia (HHT) in Italian population. A nationwide, multicentric, cross-sectional observational study was conducted on patients with HHT from five Italian HHT centers by online survey. The association between COVID-19-related signs and symptoms and nosebleeds worsening, the impact of personal protective equipment on nosebleeds pattern, and the relationship between the presence of visceral AVMs and severe outcomes were analyzed. Out of 605 total survey responses and eligible for analysis, 107 cases of COVID-19 were reported. A mild-course COVID-19 disease, not requiring hospitalization, was observed in 90.7% of patients, while the remaining eight cases needed hospitalization, two of them requiring intensive-care access. No fatal outcome was recorded and 79.3% of patients reported a complete recovery. No difference in infection risk and outcome between HHT patients and general population was evidenced. No significative interference of COVID-19 on HHT-related bleeding was found. The majority of patients received COVID-19 vaccination, with relevant impact on symptoms and need for hospitalization in case of infection. COVID-19 in HHT patients had an infection profile similar to the general population. COVID-19 course and outcome were independent from any specific HHT-related clinical features. Moreover, COVID-19 and anti-SARS-CoV-2 measures did not seem to affect significantly HHT-related bleeding profile. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11739-023-03287-8. Springer International Publishing 2023-05-04 2023 /pmc/articles/PMC10157588/ /pubmed/37140873 http://dx.doi.org/10.1007/s11739-023-03287-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Im - Original Suppressa, Patrizia Maiorano, Eugenia Gaetani, Eleonora Matti, Elina Lenato, Gennaro Mariano Serio, Ilaria Masala, Maristella Salvatora Passali, Giulio Cesare Aguglia, Maria Crocione, Claudia Lopalco, Pietro Luigi Caneschi, Francesca Musella, Valeria De Silvestri, Annalisa Gambini, Giulia Spinozzi, Giuseppe Sabbà, Carlo Pagella, Fabio Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study |
title | Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study |
title_full | Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study |
title_fullStr | Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study |
title_full_unstemmed | Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study |
title_short | Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study |
title_sort | impact of sars-cov-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive italian retrospective multicenter study |
topic | Im - Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157588/ https://www.ncbi.nlm.nih.gov/pubmed/37140873 http://dx.doi.org/10.1007/s11739-023-03287-8 |
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