ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells: SCGN regulates autophagic flux in β-cells

Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury. Our results indicate that ox-LDL treatment leads to autopha...

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Detalles Bibliográficos
Autores principales: Lv, Ying, Xiao, Sijie, Ouyang, Shuhui, Peng, Zhengliang, Wu, Li, Tang, Ziqing, Zhang, Weizheng, Cao, Renxian, Yang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157621/
https://www.ncbi.nlm.nih.gov/pubmed/36789686
http://dx.doi.org/10.3724/abbs.2022186

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