Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers

[Image: see text] Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers...

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Autores principales: Angevine, Devin J., Camacho, Kristine Joy, Zhang, Xiaotong, Rzayev, Javid, Benedict, Jason B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157684/
https://www.ncbi.nlm.nih.gov/pubmed/37151519
http://dx.doi.org/10.1021/acsomega.3c00849
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author Angevine, Devin J.
Camacho, Kristine Joy
Zhang, Xiaotong
Rzayev, Javid
Benedict, Jason B.
author_facet Angevine, Devin J.
Camacho, Kristine Joy
Zhang, Xiaotong
Rzayev, Javid
Benedict, Jason B.
author_sort Angevine, Devin J.
collection PubMed
description [Image: see text] Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers of enantiomerically pure tartaric acid are highly effective salt formers when combined with nicotine. Both salts exhibit enhanced photostability, and with a melting point of 143.1 °C, the salt prepared using d-(−)-tartaric acid possesses one of the highest melting points for a crystalline nicotine solid reported to date.
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spelling pubmed-101576842023-05-05 Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers Angevine, Devin J. Camacho, Kristine Joy Zhang, Xiaotong Rzayev, Javid Benedict, Jason B. ACS Omega [Image: see text] Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers of enantiomerically pure tartaric acid are highly effective salt formers when combined with nicotine. Both salts exhibit enhanced photostability, and with a melting point of 143.1 °C, the salt prepared using d-(−)-tartaric acid possesses one of the highest melting points for a crystalline nicotine solid reported to date. American Chemical Society 2023-04-18 /pmc/articles/PMC10157684/ /pubmed/37151519 http://dx.doi.org/10.1021/acsomega.3c00849 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Angevine, Devin J.
Camacho, Kristine Joy
Zhang, Xiaotong
Rzayev, Javid
Benedict, Jason B.
Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers
title Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers
title_full Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers
title_fullStr Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers
title_full_unstemmed Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers
title_short Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers
title_sort enhancing the stability of nicotine via crystallization using enantiopure tartaric acid salt formers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157684/
https://www.ncbi.nlm.nih.gov/pubmed/37151519
http://dx.doi.org/10.1021/acsomega.3c00849
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