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Targeting HSF1 for cancer treatment: mechanisms and inhibitor development
Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive signaling. In addition to playing critical roles in cellular heat shock response, emerging evidence suggests that HSF1 also regulates a non-heat shock responsive transcriptional network to handle metabolic, chemical, and genet...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157728/ https://www.ncbi.nlm.nih.gov/pubmed/37153737 http://dx.doi.org/10.7150/thno.82431 |
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author | Chin, Yeh Gumilar, Khanisyah E Li, Xing-Guo Tjokroprawiro, Brahmana A. Lu, Chien-Hsing Lu, Jianrong Zhou, Ming Sobol, Robert W. Tan, Ming |
author_facet | Chin, Yeh Gumilar, Khanisyah E Li, Xing-Guo Tjokroprawiro, Brahmana A. Lu, Chien-Hsing Lu, Jianrong Zhou, Ming Sobol, Robert W. Tan, Ming |
author_sort | Chin, Yeh |
collection | PubMed |
description | Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive signaling. In addition to playing critical roles in cellular heat shock response, emerging evidence suggests that HSF1 also regulates a non-heat shock responsive transcriptional network to handle metabolic, chemical, and genetic stress. The function of HSF1 in cellular transformation and cancer development has been extensively studied in recent years. Due to important roles for HSF1 for coping with various stressful cellular states, research on HSF1 has been very active. New functions and molecular mechanisms underlying these functions have been continuously discovered, providing new targets for novel cancer treatment strategies. In this article, we review the essential roles and mechanisms of HSF1 action in cancer cells, focusing more on recently discovered functions and their underlying mechanisms to reflect the new advances in cancer biology. In addition, we emphasize new advances with regard to HSF1 inhibitors for cancer drug development. |
format | Online Article Text |
id | pubmed-10157728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-101577282023-05-05 Targeting HSF1 for cancer treatment: mechanisms and inhibitor development Chin, Yeh Gumilar, Khanisyah E Li, Xing-Guo Tjokroprawiro, Brahmana A. Lu, Chien-Hsing Lu, Jianrong Zhou, Ming Sobol, Robert W. Tan, Ming Theranostics Review Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive signaling. In addition to playing critical roles in cellular heat shock response, emerging evidence suggests that HSF1 also regulates a non-heat shock responsive transcriptional network to handle metabolic, chemical, and genetic stress. The function of HSF1 in cellular transformation and cancer development has been extensively studied in recent years. Due to important roles for HSF1 for coping with various stressful cellular states, research on HSF1 has been very active. New functions and molecular mechanisms underlying these functions have been continuously discovered, providing new targets for novel cancer treatment strategies. In this article, we review the essential roles and mechanisms of HSF1 action in cancer cells, focusing more on recently discovered functions and their underlying mechanisms to reflect the new advances in cancer biology. In addition, we emphasize new advances with regard to HSF1 inhibitors for cancer drug development. Ivyspring International Publisher 2023-04-17 /pmc/articles/PMC10157728/ /pubmed/37153737 http://dx.doi.org/10.7150/thno.82431 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Chin, Yeh Gumilar, Khanisyah E Li, Xing-Guo Tjokroprawiro, Brahmana A. Lu, Chien-Hsing Lu, Jianrong Zhou, Ming Sobol, Robert W. Tan, Ming Targeting HSF1 for cancer treatment: mechanisms and inhibitor development |
title | Targeting HSF1 for cancer treatment: mechanisms and inhibitor development |
title_full | Targeting HSF1 for cancer treatment: mechanisms and inhibitor development |
title_fullStr | Targeting HSF1 for cancer treatment: mechanisms and inhibitor development |
title_full_unstemmed | Targeting HSF1 for cancer treatment: mechanisms and inhibitor development |
title_short | Targeting HSF1 for cancer treatment: mechanisms and inhibitor development |
title_sort | targeting hsf1 for cancer treatment: mechanisms and inhibitor development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157728/ https://www.ncbi.nlm.nih.gov/pubmed/37153737 http://dx.doi.org/10.7150/thno.82431 |
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